NFL 2022 Week 5 Lines: Point Spreads, Betting Odds, Schedule

The NFL Week 5 betting lines suggest that the upcoming schedule could have more one-sided games than usual for the 2022 season. Six teams are favored by at least seven points, and only two contests feature a point spread of less than a field goal.

Sunday's game between the Buffalo Bills and Pittsburgh Steelers features the biggest line of the season. According to the opening betting odds, Buffalo is favored by 14 points over Pittsburgh, which lost its third straight game in Week 4. Pittsburgh rookie quarterback Kenny Pickett is expected to make his first start for the Steelers after replacing Mitchell Trubisky in the second half of the team's loss to the New York Jets.

The Tampa Bay Buccaneers are the second-biggest favorites of Week 5. The Atlanta Falcons are getting eight points in Tampa Bay for what has become a key NFC South matchup. The winner will take sole possession of first place. The Falcons have tied the Buccaneers atop the division with two straight wins. Tampa Bay has lost consecutive games against the Packers and Kansas City Chiefs.

Kansas City is favored by 7.5 points over the Las Vegas Raiders on "Monday Night Football." Green Bay is also a 7.5-point favorite in a nationally televised game. The Packers are scheduled to face the New York Giants in London. Both the Packers and Giants have 3-1 records.

The Jacksonville Jaguars and Minnesota Vikings are touchdown favorites in Week 5. The undefeated Philadelphia Eagles are the biggest road favorites on the schedule, laying 5.5 points against the Arizona Cardinals.

The New Orleans Saints are favored by 4.5 points over the Seattle Seahawks, despite their 1-3 record. The Tennessee Titans, Los Angeles Chargers and San Francisco 49ers are all road favorites, even though none of them are above .500.

Here are the complete betting lines for all the Week 5 games, including the point spreads and totals, via FanDuel Sportsbook.

Thursday, Oct. 6

Indianapolis Colts (+3) at Denver Broncos, 43.5

Sunday. Oct. 9

New York Giants (+7.5) vs. Green Bay Packers, 41.5 (London)

Seattle Seahawks (+4.5) at New Orleans Saints, 45.5

Pittsburgh Steelers (+14) at Buffalo Bills, 46.5

Chicago Bears (+7) at Minnesota Vikings, 43

Houston Texans (+7) at Jacksonville Jaguars, 44.5

Miami Dolphins (-3) at New York Jets, 44.5

Atlanta Falcons (+8) at Tampa Bay Buccaneers, 48.5

Detroit Lions (+2.5) at New England Patriots, 47.5