Through the first four weeks of the 2022 NFL season, six teams have exactly three wins against the spread. Eight teams are 1-3 against the spread. The Atlanta Falcons are the only team that has covered the spread in every game.

Here are picks against the spread for every game in Week 5 and updated betting odds from FanDuel and DraftKings Sportsbook.

Indianapolis Colts (+3) at Denver Broncos

Road teams are 0-3 straight up and against the spread on short rest in "Thursday Night Football" games this season. If Colts running back Jonathan Taylor plays, he'll be far less than 100% because of an ankle injury. Denver's offense has been bad, but Indianapolis has scored the fewest points in the league.

Prediction ATS: Denver

New York Giants (+7.5) vs. Green Bay Packers (London)

Even though both teams are 3-1, the Packers are still much better than the Giants. With Aaron Rodgers under center, Green Bay has an enormous advantage at the most important position. Daniel Jones is throwing for 157.8 yards per game and left the last game with an ankle injury. The Packers are fifth in total defense and sixth in total offense.

Prediction ATS: Green Bay

Seattle Seahawks (+5.5) at New Orleans Saints

Why is New Orleans favored by nearly a touchdown? The Seahawks have a better record than the Saints. Geno Smith has played better than Andy Dalton and Jameis Winston. Seattle is much healthier on offense. The Saints are 2-6 in their last eight home games.

Prediction ATS: Seattle

Pittsburgh Steelers (+14) at Buffalo Bills

Prior to beating the Ravens by a field goal in Week 4, the Bills' last 20 regular-season victories had come by double digits. Buffalo has outscored its opponents by 56 points in four games. Josh Allen produces more yards per game than the entire Steelers offense. Kenny Pickett is likely to struggle in his first start against the league's No. 1 passing defense

Prediction ATS: Buffalo

Chicago Bears (+7) at Minnesota Vikings

Minnesota hasn't covered a spread since the opener, only narrowly defeating a couple of 1-3 teams in the last two weeks. Chicago ranks fourth in total defense and has held three of its opponents to 20 points or fewer. The Vikings only have a plus-six point differential on the season.

Prediction ATS: Chicago

Houston Texans (+7) at Jacksonville Jaguars

The Texans are winless but have managed to stay competitive in all four games, being outscored by an average of five points per contest. Houston has won eight straight games against Jacksonville. Trevor Lawrence has six turnovers. The Jaguars should end their losing streak against the Texans, though it could be a one-score game.

Prediction ATS: Houston

Miami Dolphins (-3) at New York Jets

New York's 2-2 record doesn't mean it's a legitimate playoff contender. The Jets a pair of double-digit, fourth-quarter comebacks to get both victories. Miami has 10 days to prepare for an offense that ranks 24th in yards per play. The Dolphins are second in yards per play and still a dangerous unit with Teddy Bridgewater under center.

Prediction ATS: Miami

Atlanta Falcons (+8.5) at Tampa Bay Buccaneers

The Buccaneers could come out firing Sunday after two straight losses. Tom Brady had 385 passing yards and Tampa Bay scored a season-high 31 points in Week 4 with the receiving corps finally intact. The Bucs gave up the fewest points in the league before facing Patrick Mahomes and Kansas City's explosive offense. Atlanta's perfect record against the spread can only last for so long.

Prediction ATS: Tampa Bay

Detroit Lions (+3) at New England Patriots

Bailey Zappe looked more than competent in his first action as the Patriots quarterback at Lambeau Field. Things get much easier for New England in Week 5 when they welcome in the league's worst defense. Detroit's two best offense weapons are both banged up.

Prediction ATS: New England

Tennessee Titans (-2.5) at Washington Commanders

Washington has been the league's worst team since beating Jacksonville in the opener. The Commanders have lost three straight games by at least nine points. Washington has given up more than 21 points in every game. Carson Wentz has been sacked a league-high 17 times.

Prediction ATS: Tennessee

Los Angeles Chargers (-3) at Cleveland Browns

Don't be surprised if Cleveland pulls off the outright upset. Los Angeles is still missing its best offensive tackle and best defensive player. Keenan Allen has missed three straight games with an injury. The Browns are second in rushing yards per game, and the Chargers give up the second-most yards per carry.

Prediction ATS: Cleveland

San Francisco 49ers (-6.5) at Carolina Panthers

As terrific as San Francisco's defense has been, the 49ers are probably laying too many points on the road. The 49ers lost outright to the Bears as 6.5-point road favorites in Week 1. San Francisco is 24th in total offense and 28th in points per game. Jimmy Garoppolo is only completing 61% of his passes.

Prediction ATS: Carolina

Philadelphia Eagles (-5) at Arizona Cardinals

Until they finally lose, it might be safe to assume that the Eagles are going to win each game by at least a touchdown. Philadelphia is the league's lone perfect team and has held a minimum 15-point lead in every fourth quarter. Both of Arizona's wins have come against teams that enter Week 5 with a 1-3 record.

Prediction ATS: Philadelphia

Dallas Cowboys (+4.5) at Los Angeles Rams

There should probably be some concerns in Los Angeles. The Rams have played two good defenses and been held to 19 total points in those contests. Matthew Stafford has been sacked 14 games in those games. Dallas is second in team sacks, led by arguably the league's top pass rusher.

Prediction ATS: Dallas

Cincinnati Bengals (+3) at Baltimore Ravens

Both AFC North teams enter this matchup with a 2-2 record, but the Ravens are probably the better team. Baltimore blew three-score leads against both Buffalo and Miami. Cincinnati's offense has been a little underwhelming, ranking outside of the top-10 in yards per play, yards per game and points per game.

Prediction ATS: Baltimore

Las Vegas Raiders (+7) at Kansas City Chiefs

The Chiefs are two games ahead of the Raiders in the AFC West, and Kansas City should put to rest any dreams that Las Vegas might have of winning the division. Kansas City ranks second with 32.3 points per game. The Raiders haven't kept any opponent below 23 points. Patrick Mahomes is 7-1 against the Raiders in his career with 22 touchdown passes and three interceptions.

Prediction ATS: Kansas City

Season Record: 30-32-2

Mike Evans Tom Brady Buccaneers Fan
Mike Evans #13 of the Tampa Bay Buccaneers celebrates with fans after scoring a touchdown in the first quarter against the Chicago Bears in the game at Raymond James Stadium on October 24, 2021 in Tampa, Florida. Mike Ehrmann/Getty Images