Donald Trump
In this photo, U.S. President Donald Trump addresses supporters as he speaks at the Indiana State Fairgrounds & Event Center September 27, 2017 in Indianapolis, Indiana. Getty Images / Joshua Lott

Not one to mince words, President Donald Trump has time and again called out American business leaders for taking a stance that apparently went against his interests.

The latest to have incurred Trump's Twitter wrath is Facebook CEO Mark Zuckerberg, whose social network the president termed "anti-Trump" and blamed it for "collusion" with "fake news" disseminators such as the New York Times and the Washington Post.

Zuckerberg didn't let the accusation of bias pass, and wrote a FB post about it Wednesday, rejecting the president's allegation that Facebook was always against him.

He claimed the social network was an overall force for good during the 2016 U.S. presidential election campaign.

"Trump says Facebook is against him. Liberals say we helped Trump. Both sides are upset about ideas and content they don't like. That's what running a platform for all ideas looks like," he wrote.

Zuckerberg also regretted dismissing the question that was asked regarding the impact of the social network on the election campaign of 2016. He had then dismissed the notion as crazy.

"After the election, I made a comment that I thought the idea misinformation on Facebook changed the outcome of the election was a crazy idea. Calling that crazy was dismissive and I regret it. This is too important an issue to be dismissive," he wrote.

See posts, photos and more on Facebook.

This is not the first time that Trump has locked horns with a big business leader in America.

In August, the president had gone after Amazon CEO Jeff Bezos and accused him of hurting “tax-paying retailers” and eliminating jobs.

“Amazon is doing great damage to tax-paying retailers. Towns, cities, and states throughout the U.S. are being hurt - many jobs being lost!" he tweeted.

But that was just the latest of the feud between Trump and Bezos, who also owns the Washington Post.

Back in December 2015, Trump had accused Bezos of using the Washington Post "scam" to save "no-profit company" Amazon.

Bezos responded with a tinge of humor to Trump's tirade, tweeting that he'd like to "send Donald to space" on the Blue Origin, his private space firm.

The president also ran into trouble in August with Merck CEO Kenneth Frazier, Richard Trumka and Thea Lee of the American Federation of Labor and Congress of Industrial Organizations(ACL-CIO), Intel CEO Brian Krzanich, and Under Armour CEO Kevin Plank, after they left American Manufacturing Council to protest Trump’s response to the white nationalist protest in Charlottesville, Virginia.

“President Trump’s remarks today repudiate his forced remarks yesterday about the KKK and neo-Nazis,” ACL-CIO president Trumka had said.

“We must resign on behalf of America’s working people, who reject all notions of the legitimacy of these bigoted groups.”

Trump later took to Twitter to comment on the executives’ withdrawal from the council, saying, “Now that Ken Frazier of Merck Pharma has resigned from President's Manufacturing Council, he will have more time to LOWER RIPOFF DRUG PRICES!”