From jokes about the warning labels on bleach to somber reflections on the past four years, comedians welcomed President Joe Biden to office in true late-night fashion.

Talk show hosts took turns in both welcoming Biden to the White House and saying farewell to former President Donald Trump. Jimmy Kimmel kicked it off with a departing message for the former president.

On “The Tonight Show” with Jimmy Fallon, the "Saturday Night Live" alum made a jab at the long list of pardons Trump gave in his final act as president, noting this is probably the last time we’ll hear Steve Bannon, a former chief strategist accused of defrauding investors in a Trump border wall scheme, and Lil Wayne, the rapper cleared of a 10-year-old weapons charge, in the same sentence.

Another "SNL" alumnus, Seth Meyers, said during his “Late Night” monologue that he’s been waiting years to say these words.

For James Corden, the host of “The Late Late Show," wondered if Trump watched Biden’s inauguration speech and got confused by the theme of unity.

On “The Late Show with Stephen Colbert,” the host had a bit of fun with the post-inaugural events hosted by Tom Hanks.

Celebrities and dignitaries alike weighed in on the changing of guard in the White House. On Twitter, Oprah Winfrey said she wept as Kamala Harris took the oath of office to become the first woman and the first person of African and Asian descent to hold the vice presidency.

Former first Lady Michelle Obama, meanwhile, reflected on the somber occasion. “Right now, I'm feeling more than just relief at putting the past four years behind us,” she said. “I'm feeling genuinely hopeful for what's to come.”

The president himself has shown his sense of humor. Here’s the president on "Late Night With David Letterman" from 2007, when then-Sen. Biden was launching his first bid for the White House.

Joining the Senate in the early 1970s, Biden realized his long-held dream to become president by taking the oath of office on Wednesday.