The 2022 college football season officially begins Saturday with the year's first slate of games. Most teams don't start their schedule until Sept. 1, but a handful of FBS schools are set to make their debuts in Week 0.

The Week 0 schedule doesn't feature any of college football's top-ranked teams, though a few teams from Power Five conferences start the season Saturday. Nebraska takes on Northwestern in arguably the day's biggest game, featuring a pair of Big Ten rivals.

Nebraska is favored by two touchdowns in a game that will take place in Dublin, Ireland. The Cornhuskers and Wildcats finished at the bottom of the Big Ten standings last season, going 1-8 in conference play.

Nebraska dominated last year's matchup against Northwestern, winning 56-7 at home. It was the largest margin of victory for any Big Ten game in the 2021 season. It also marked Nebraska's only conference win of the year.

A third Big Ten school is on the schedule with Illinois' matchup against Wyoming. The Illini are close to double-digit favorites over the visiting Cowboys. Illinois defeated Nebraska in Week 0 to kick off last season.

Vanderbilt is the lone SEC team on Saturday's schedule. The Commodores are favored by a touchdown in Hawaii.

Utah State is the biggest favorite on the schedule. The Aggies are laying 27.5 points at home against Connecticut. Utah State won last year's Mountain West Championship before defeating Oregon State in the LA Bowl.

Here's a look at the biggest games on the Week 0 schedule and the betting odds for each contest. Point spreads and totals come from FanDuel Sportsbook.

Saturday, Aug. 27

Nebraska (-13.5) at Northwestern, 50.5

Wyoming (+9.5) at Illinois, 43.5

Connecticut (+27.5) at Utah State, 59.5

Charlotte (+7.5) at Florida Atlantic, 57.5

North Texas (-1.5) at UTEP, 54.5

Nevada (-8.5) at New Mexico State, 50.5

Vanderbilt (-6.5) at Hawaii, 54.5