Critics' Choice Awards: Chelsea Handler Takes A Dig At Prince Harry [Watch]

Comedian Chelsea Handler took a dig at Prince Harry while hosting the 28th Critics' Choice Awards on Sunday night. She also criticized Hollywood studios for treating male and female directors differently.

In her opening monologue, Handler praised actress Niecy Nash for her performance in Netflix's "Monster: The Jeffrey Dahmer Story," noting it became "the third-highest viewed show on Netflix with a combined watch time of 1 billion hours, which apparently is the same amount of time we're going to have to listen to Prince Harry talk about his frostbitten penis."

"It's enough, already," she added.

The 47-year-old comedian praised actress Julia Roberts and mocked celebrities who use ozempic — a diabetes medication — for weight loss.

"We love you, Julia," Handler said. "The word 'Gaslighting' was actually Merriam Webster's word of the year. And for those of you who don't know, gaslighting is when someone tries to convince you that your own perceptions of reality are wrong. Like when celebrities say they lost weight by drinking water, but really it's because everyone's on Ozempic."

Handler then went after Hollywood studios, saying they would allot more budget for male directors like James Cameron compared to female directors like Sarah Polley.

"I don't want to say that studios treat male and female directors differently, but James Cameron was given a budget of $350 million and Sarah Polley had to film Women Talking in a barn," the comedian said after praising "Avatar: The Way of Water" for being one of the biggest movies last year.

"But, I guess it all worked out because they're both up for Best Picture. Women Talking is a powerful movie, but a warning to men: Women will definitely be talking," she added.

Handler also gave a shout-out to Viola Davis for working in an action-packed movie, "The Woman King."

"As part of Viola's training for the film, she was given a DNA test to determine the best workout regimen for her genetic make-up, which also revealed that she's Nick Cannon's daughter," the comedian said.