The death toll from a massive earthquake in Haiti soared past 2,000 on Wednesday as relief workers warned of challenges to aid efforts five days after thousands of people were left homeless.

The number of people killed in Saturday's devastating quake has risen by almost 250 to 2,189, the country's civil protection agency said.

Earthquake survivors built makeshift shelters near Les Cayes, close to the epicenter of the quake
Earthquake survivors built makeshift shelters near Les Cayes, close to the epicenter of the quake AFP / Reginald LOUISSAINT JR

"There are around 600,000 people who were directly affected and who need immediate humanitarian assistance," said Jerry Chandler, speaking from the emergency operations center in the capital Port-au-Prince.

"We had to find ways of ensuring security, which remains a significant challenge."

Earthquake survivors built makeshift shelters near Les Cayes, close to the epicenter of the quake
Earthquake survivors built makeshift shelters near Les Cayes, close to the epicenter of the quake AFP / Reginald LOUISSAINT JR

The quake also injured at least 12,268 people and damaged or destroyed tens of thousands of buildings in the Caribbean nation, which has still not recovered from the devastating earthquake of 2010.

On Tuesday, many Haitians left with no shelter by the 7.2-magnitude earthquake had to endure lashing winds and pouring rain as Tropical Storm Grace passed over the country.

A young man injured by the earthquake lies on a bed at the "Communautaire de Référence" hospital in Port-Salut, Haiti
A young man injured by the earthquake lies on a bed at the "Communautaire de Référence" hospital in Port-Salut, Haiti AFP / Reginald LOUISSAINT JR

Even before the powerful earthquake, Haiti, one of the world's poorest countries, was wracked by a mounting Covid-19 crisis and political chaos that culminated last month with the assassination of president Jovenel Moise.

And while gang violence plagued the poverty-stricken neighbourhood of Martissant near the capital in the weeks since early June, that threat appears to have diminished for now with an informal truce in place, easing fears that gun violence could impact the flow of convoys out of Port-au-Prince.

The Haitian government has declared a month-long state of emergency in the four provinces impacted by the latest quake
The Haitian government has declared a month-long state of emergency in the four provinces impacted by the latest quake AFP / Reginald LOUISSAINT JR
The number of people killed in Saturday's devastating quake has risen by almost 250 to 2,189, Haiti's civil protection agency says
The number of people killed in Saturday's devastating quake has risen by almost 250 to 2,189, Haiti's civil protection agency says AFP / Reginald LOUISSAINT JR

But relief workers still face other challenges.

"Sometimes we've been confronted by frustrated and impatient people, who have caused problems and blocked our convoys," Chandler said.

The government has declared a month-long state of emergency in the four provinces impacted by the latest quake.

In the hard-to-reach area of Maniche some 120 miles from the capital, residents are still waiting for aid.

"The institutions we used to have ... are in ruins," local resident Rose Hurguelle Point du Jour said, adding that the church, parish and clinic have all been totally destroyed.

Another resident, Geordany Bellevue, fears for people living in remote and landlocked parts of Maniche.

"There were a lot of mudslides in the mountains that injured and killed a lot of people. Some are missing and we don't have the means to go find them," the 32-year-old said.

"It was already hard to get aid here in the center of Maniche, so when it comes, it never reaches the disaster victims in the remote areas."

Haiti's civil protection agency said Wednesday that at least 332 people are still missing.

Meanwhile aid agency USAID, which has been leading US relief efforts, said in a statement on Wednesday that "many roads remain impassable in some areas."

The agency added that it and its partners have relied on air and sea routes to reach some victims, including supporting the World Food Programme's barge service "to deliver relief supplies and personnel to southwestern Haiti."