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Saul Berenson (Mandy Patinkin, left) and Carrie Mathison (Claire Danes), pictured in a scene from "Homeland" Season 4, will not be on the best of terms when the fifth season premiere. Showtime

When the fourth season of Showtime’s “Homeland” concluded last winter, viewers were left wondering what would become of Carrie Mathison (Claire Danes) and Saul Berenson’s (Mandy Patinkin) relationship. As fans will remember, Carrie caught Saul chatting up a suspected enemy, two-timing CIA agent Dar Adal (F. Murray Abraham) in the season closer. The trailer for Season 5 hints that their bond will not be as strong as its been in seasons past.

When Season 5 premiers on Oct. 4, it will pick up over two years after the events in the finale. Carrie will be based in Berlin, Germany, working as the head of security for a German philanthropist. The trailer shows her content being a working mother — her daughter Frannie with late Nicholas Brody (Damian Lewis) even makes a few cameos. But it appears her work with the CIA is for from over. When Saul is alerted to a data breach in Berlin, he questions if Carrie had something to do with it.

“I know that what you’re doing will get good people hurt,” Carrie says in the trailer to an unidentified individual. A later shot shows Carrie having a conversation with Saul, telling him, “I’m just trying to do good work." Saul responds by calling her foolish.

“Well, you’re not,” he says. “You’re being naive and stupid.”

Watch the trailer for “Homeland” Season 5 below:

While it appears Carrie and Saul's relationship will be tested in Season 5, Saul does have at least one trusted ali. A previously released teaser for the forthcoming installment revealed that the Saul will befriend Peter Quinn (Rupert Friend).

“Quinn and Saul have struck up a very special friendship,” Friend says in the video. “There is no one on this planet that Saul would put more trust and faith in than Peter Quinn,” Patinkin says in another clip.

“Homeland” Season 5, episode 1, titled “Separation Anxiety,” premieres Sunday, Oct. 4, at 9 p.m. EDT on Showtime.