NFL 2016 Week 2 Lines: Point Spreads, Totals And Complete Betting Odds From Las Vegas

Cam Newton Carolina Panthers — Cam Newton and the Carolina Panthers are the biggest favorites in Week 2. They lost to the Denver Broncos at Sports Authority Field at Mile High on Sept. 8. Reuters/Mark J. Rebilas-USA TODAY Sports

Most of the games in the first week of the 2016 NFL season were decided by one possession, and Week 2 could feature just as many close contests. The schedule begins with a divisional matchup on “Thursday Night Football” that includes the schedule’s smallest betting line.

The Buffalo Bills opened the week as home favorites against the New York Jets, but that quickly changed. The news that Sammy Watkins is battling a foot injury, combined with Buffalo’s anemic offense in their season opener, has the gambling public backing the Jets. The point spread has moved to a pick’em in less than two days, and New York could be favored before it’s all said and done.

There was only one double-digit favorite in Week 1, and the case is the same in Week 2. The Carolina Panthers are giving the San Francisco 49ers two touchdowns, though that could change in the coming days. Carolina lost to the Denver Broncos in the season’s first game, and San Francisco closed out Week 1 with a shutout of the Los Angeles Rams.

The contest between the New York Giants and New Orleans Saints is expected to be Week 2's highest-scoring affair. The teams ranked in the bottom two in total defense last season, and the Saints don’t look to be much improved after allowing 35 points on Sunday. Spending more money on their defense than any other team looks to be paying off for the Giants, who only surrendered one touchdown in Week 1.

A few sportsbooks list the Rams as 3.5-point underdogs after their loss on Monday night, but no over/under has been set for their matchup with the Seattle Seahawks. L.A. had the worst season debut of any team with just 185 yards of total offense, and it might be only a matter of time before quarterback Case Keenum loses his starting job.

All three primetime games feature betting lines of three points or less. The Green Bay Packers are small road favorites against the Minnesota Vikings on Sunday night, while the Philadelphia Eagles are small underdogs in their visit to Chicago on “Monday Night Football.”

Below are the complete betting lines for all the Week 2 games, including the point spreads and totals. These are the consensus odds from multiple sportsbooks in Las Vegas and online, via OddsShark.

Thursday, Sept. 15

New York Jets (PK) at Buffalo Bills, 40.5

Sunday, Sept. 18

Tennessee Titans (+5.5) at Detroit Lions, 47

Kansas City Chiefs (+2.5) at Houston Texans, 43.5

Miami Dolphins (+6.5) at New England Patriots, 41.5

Baltimore Ravens (-7) at Cleveland Browns, 43

Cincinnati Bengals (+3.5) at Pittsburgh Steelers, 47.5

Dallas Cowboys (+3.5) at Washington Redskins, 44.5

New Orleans Saints (+5) at New York Giants, 53

San Francisco 49ers (+14) at Carolina Panthers, 48.5

Tampa Bay Buccaneers (+6.5) at Arizona Cardinals, 50