NFL 2021 Week 10 Lines: Opening Point Spreads, Betting Odds, Schedule

Week 10 of the 2021 NFL season includes a few key divisional matchups, two of which will be featured in primetime. The Kansas City Chiefs and Los Angeles Rams have opened as betting favorites in arguably the biggest games on the upcoming schedule.

Kansas City is a three-point road favorite against the Las Vegas Raiders on “Sunday Night Football,” even though the Chiefs are behind the Raiders in the AFC West standings. Los Angeles is laying a field goal in their NFC West matchup with the San Francisco 49ers on “Monday Night Football.”

There isn’t as much on the line in the “Thursday Night Football” game. The Baltimore Ravens are big favorites against the Miami Dolphins, who have already been all-but eliminated from playoff contention.

Based on records, the best Week 10 game involves the New Orleans Saints and Tennessee Titans. Both teams recently lost one of their most important players with quarterback Jameis Winston and running back Derrick Henry suffering serious injuries.

The Pittsburgh Steelers and Dallas Cowboys are favored by more than a touchdown at home. The Tampa Bay Buccaneers are laying 7.5 points in Washington in a rematch from last season’s playoffs.

Betting lines for a few games aren’t yet available. It isn’t yet known Kyler Murray or Aaron Rodgers will be available in Week 10. The Indianapolis Colts just beat the New York Jets Thursday night.

The Chicago Bears, Cincinnati Bengals, New York Giants and Houston Texans have byes in Week 10.

Here are the opening betting lines for the games in Week 10 of the 2021 NFL season, including the point spreads and totals, via DraftKings Sportsbook.

Thursday, Nov. 11

Baltimore Ravens (-6.5) at Miami Dolphins, 48

Sunday, Nov. 14

New Orleans Saints (+ 2.5) at Tennessee Titans, 44.5

Tampa Bay Buccaneers (-7.5) at Washington Football Team, 51

Detroit Lions (+9.5) at Pittsburgh Steelers, 44

Cleveland Browns (+3) at New England Patriots, 44.5

Atlanta Falcons (+9.5) at Dallas Cowboys, 50.5

Buffalo Bills (N/A) at New York Jets

Jacksonville Jaguars (N/A) at Indianapolis Colts

Carolina Panthers (N/A) at Arizona Cardinals

Seattle Seahawks (N/A) at Green Bay Packers