NFL 2021 Week 2 Lines: Point Spreads, Betting Odds, Schedule

The first NFL Sunday of the 2021 NFL season featured some major surprises. Half of the defending division champions lost straight up as betting favorites in the opener.

Coming off his third NFL MVP award, Aaron Rodgers was as bad as any starting quarterback. Josh Allen and the Buffalo Bills came up short at home. The Cleveland Browns blew a chance to upset the Kansas City Chiefs.

All of those teams, along with other Week 1 losers, are expected to bounce back in Week 2.

The Browns, Green Bay Packers, and Tampa Bay Buccaneers are double-digit favorites on the upcoming schedule. The Bills, San Francisco 49ers, and New Orleans Saints are road favorites against 1-0 teams.

Only two games feature a point spread of less than a field goal. Five games have an over/under north of 50.

Here are the complete betting lines for all the Week 2 games, including the point spreads and totals, via FanDuel Sportsbook.

Thursday, Sept. 16

New York Giants (+4) at Washington Football Team, 42.5

Sunday, Sept. 19

Las Vegas Raiders (+6.5) at Pittsburgh Steelers, 49.5

Cincinnati Bengals (+3.5) at Chicago Bears, 45.5

Houston Texans (+12.5) at Cleveland Browns, 47.5

Los Angeles Rams (-4.5) at Indianapolis Colts, 47.5

Buffalo Bills (-3.5) at Miami Dolphins, 48.5

New England Patriots (-4) at New York Jets, 43.5

San Francisco 49ers (-3.5) at Philadelphia Eagles, 48.5