NFL 2022 Week 2 Lines: Point Spreads, Betting Odds, Schedule

A few marquee teams that started the 2022 NFL season with a loss are expected to bounce back in a big way, according to the opening betting odds. Three of last year's playoff teams were beaten in Week 1 and are heavy favorites in Week 2.

The early Week 2 lines favor the Los Angeles Rams, Green Bay Packers and San Francisco 49ers by more than a touchdown. Two other games on the Week 2 schedule feature points spreads of at least nine points.

The Rams are tied as the biggest betting favorites in Week 2 after getting blown out by the Buffalo Bills 31-10 in the Kickoff Game. The defending Super Bowl champs are laying 10.5 points against the visiting Atlanta Falcons.

The Denver Broncos are also 10.5-point favorites in Week 2, prior to their season opener on "Monday Night Football" tonight. Buffalo is a 9.5-point favorite against the Tennessee Titans as part of the upcoming Monday night doubleheader.

The upcoming "Sunday Night Football" matchup between the Packers and Chicago Bears features a 9.5-point spread. Green Bay wasn't very competitive in its 23-7 loss in Minnesota. Aaron Rodgers was limited to 195 passing yards without a true No. 1 receiver on the roster.

The Bears defeated the 49ers 19-10 in the biggest upset of Week 1. San Francisco is favored by 8.5 points against the Seattle Seahawks in Week 2. Trey Lance completed fewer than half of his passes for 164 yards in the opener.

Now that Dak Prescott is expected to miss up to two months with a hand injury, the Dallas Cowboys are the biggest home underdogs on the schedule. The Cincinnati Bengals are 6.5-point favorites at AT&T Stadium. The Bengals were upset by the Pittsburgh Steelers in Week 1.

Here are the complete betting lines for all the Week 2 games, including the point spreads and totals, via FanDuel Sportsbook.

Thursday, Sept. 15

Los Angeles Chargers (+3.5) at Kansas City Chiefs, 53.5

Sunday, Sept. 18

New York Jets (+6.5) at Cleveland Browns, 40.5

Washington Commanders (+1.5) at Detroit Lions, 48.5

Tampa Bay Buccaneers (-2.5) at New Orleans Saints, 45.5

Carolina Panthers (+2.5) at New York Giants, 42.5

New England Patriots (-1) at Pittsburgh Steelers, 40.5

Indianapolis Colts (-4.5) at Jacksonville Jaguars, 45.5

Miami Dolphins (+3.5) at Baltimore Ravens, 44.5

Atlanta Falcons (+10.5) at Los Angeles Rams, 47.5