NFL Game Picks: Predictions and Betting Lines for Week 2 [Sunday and Monday]

There are several interesting contests in the second week of the NFL Season. Here is breakdown of the games for your office pool.

New Orleans Saints at Carolina Panthers. QB Cam Newton should bounce back from an uneven performance in Week One. With home field advantage, the Panthers will likely step up against a tough New Orleans squad. The Saints defense gave up 459 total yards to the Redskins' offense on Sunday and their defense may have trouble containing Newton.

Line: Saints by 3; Over/Under: 44.5
Prediction: Panthers over the Saints, 28-20

Arizona Cardinals at New England Patriots. The Patriots dismantled the Titans on the road in Week One, and there's no reason to suggest they won't do the same to the Cardinals at home. Arizona held off a tough Seahawks team in Week One, but the running game was absolutely dreadful.

Line: Patriots by 14; Over/Under: 48.5
Prediction: Patriots beat the Cardinals, 36-17.

Oakland Raiders at Miami Dolphins. Oakland's offense will likely rebound from a terrible effort against the Chargers, but QB Ryan Tannehill has one game of NFL experience under his belt, which should help in his first home game. Expect a big game from RB Reggie Bush.

Line: Raiders by 3; Over/Under: 39
Prediction: Dolphins edge the Raiders, 17-16

Minnesota Vikings at Indianapolis Colts. A battle of young quarterbacks should end in the Colts' favor as Andrew Luck will have fewer errors against the Vikings. Adrian Peterson and Percy Harvin need big games for Minnesota to pull off the win.

Line: Vikings by 2; Over/Under: 44.5
Prediction: Colts edge the Vikings, 24-21

Cleveland Browns at Cincinnati Bengals. The Browns won't have CB Joe Haden, and that should help Bengals QB Andy Dalton, who didn't throw for a touchdown against a tough Ravens defense in Week One. Browns rookie QB Brandon Weeden should have more struggles this week.
Line: Bengals by 7; Over/Under: 38.5
Prediction: Bengals over Browns, 24-10

Baltimore Ravens at Philadelphia Eagles. QB Michael Vick will not throw four interceptions at home, despite playing an excellent defense. While Philadelphia's offense will bounce back, the Ravens are coming off an excellent Week One when they trounced the Bengals. Baltimore's offense has a tough test against this Eagles defense, and the secondary will likely thrive with wide outs Jeremy Maclin and DeSean Jackson questionable.
Line: Ravens by 3; Over/Under: 46.5
Prediction: Ravens over Eagles, 28-20

Houston Texans at Jacksonville Jaguars. Jacksonville QB Blaine Gabbert is coming off a strong Week One, while RB Maurice Jones-Drew is due for a better game following missing the preseason. But this Texans squad is too tough, as QB Matt Schaub has a lot of weapons to hold off the Jags.
Line: Texans by 7.5; Over/Under: 41
Prediction: Texans over Jaguars, 24-14

Kansas City Chiefs at Buffalo Bills. QB Matt Cassel had three turnovers for the Chiefs in Week One, but should settle down against a Bills defense that looked awful against the Jets. The pressure is on QB Ryan Fitzpatrick, who had trouble finding receivers and will be without WR David Nelson. RB C. J. Spiller is a talent, so look for the Bills to use him more on Sunday.
Line: Chiefs by 3; Over/Under: 45
Prediction: Chiefs edge Bills, 24-23

Tampa Bay Buccaneers at New York Giants. RB Doug Martin might be a key find for the Buccaneers, but the Giants are desperate to bounce back from their loss to the Cowboys. Expect the Giants defense to give QB Josh Freeman problems, and for Eli Manning to have a very strong game.
Line: Giants by 7; Over/Under: 44
Prediction: Giants over Buccaneers, 38-17

Dallas Cowboys at Seattle Seahawks. The Seahawks offense failed to generate much offense against the Cardinals, and now must face an even tough Cowboys squad. QB Tony Romo is a man on a mission to make the postseason, and should he have time to throw the ball, could have an excellent game with TE Jason Witten in better shape.

Line: Cowboys by 3; Over/Under: 42.5
Prediction: Cowboys over Seahawks, 21-10

Washington Redskins at St. Louis Rams. QB Robert Griffin III is the new and exciting addition to the NFL, but should suffer a bit of a letdown against a defense that is expected to perform better than they did at Detroit in Week One. Expect RB Stephen Jackson to have a better effort for St. Louis.
Line: Redskins by 3; Over/Under: 44.5
Prediction: Rams edge Redskins, 28-27

Tennessee Titans at San Diego Chargers. QB Jake Locker will have WR Kenny Britt, which should help the offense immensely. Philip Rivers is still eager to prove that he is among the elite QBs in the NFL, and should have a big game with TE Antonio Gates returning, but it may not be enough with a rather weak running game.
Line: Chargers by 6; Over/Under: 43
Prediction: Titans edge Chargers, 21-20

New York Jets at Pittsburgh Steelers. QB Mark Sanchez showed he is better than many people give him credit for in Week One, but the Steelers are at home where they are always tough. The Steelers defense will be hungry despite the possible absence of S Troy Polamalu and LB James Harrison. New York will miss CB Darrelle Revis and TE Dustin Keller.
Line: Steelers by 6; Over/Under: 41.5
Prediction: Steelers over Jets, 24-14

Detroit Lions at San Francisco 49ers. QB Matthew Stafford has a tough test as the 49ers have perhaps the best defense in the NFC. The 49ers will likely be tough at home, and should hold off the Lions' offense in a low scoring game.

Line: 49ers by 7; Over/Under: 47
Prediction: 49ers over Lions, 20-10

Monday Night Football
Denver Broncos at Atlanta Falcons. Expect a lot of points and for Denver to look sharp, as the offense will continue to click under Peyton Manning. Matt Ryan will have a tougher time against Denver than he did against Kansas City
Line: Falcons by 3; Over/Under: 51
Prediction: Broncos over Falcons, 30-21