The home team is favored in every game on Wild-Card Weekend as six matchups over three days kick off the 2022 NFL playoffs. Two first-round games feature a point spread north of a touchdown, and every contest has a betting line of at least three points.

The odds suggest that the San Francisco 49ers have the best chance of pulling off an upset. Dallas is only favored by a field goal over the visiting 49ers. San Francisco finished the regular season with seven wins in the last nine games.

The reigning AFC champs are the biggest Wild-Card Weekend favorites. The Kansas City Chiefs are laying 12.5 points against the Pittsburgh Steelers. It was only a few weeks ago that the Chiefs jumped out to a 30-0 lead in their victory over the Steelers.

Patrick Mahomes has led Kansas City to three straight AFC Championship Games.

Tom Brady is undefeated in the playoffs as the Tampa Bay Buccaneers quarterback. Tampa Bay is an 8.5-point favorite over the Philadelphia Eagles as the Bucs continue their Super Bowl title defense.

Philadelphia has the worst record of any team in the playoffs.

The New England Patriots are underdogs in what will be the franchise’s first playoff game without Brady under center in 23 years. The Cincinnati Bengals are favored to win their first playoff game in three decades.

The over/under suggests that New England’s visit to Buffalo will be the lowest-scoring wild-card game. The Monday night matchup between the Arizona Cardinals and the Los Angeles Rams has the weekend’s highest total.

Here are the early betting lines for the 2022 wild-card games, including the point spreads and totals, via FanDuel Sportsbook.

Saturday, Jan. 15

Las Vegas Raiders (+6) at Cincinnati Bengals, 49

New England Patriots (+4.5) at Buffalo Bills, 43.5

Sunday, Jan. 16

Philadelphia Eagles (+8.5) at Tampa Bay Buccaneers, 49

San Francisco 49ers (+3) at Dallas Cowboys, 50.5

Pittsburgh Steelers (+12.5) at Kansas City Chiefs, 46.5

Monday, Jan 17

Arizona Cardinals (+4) at Los Angeles Rams, 50.5

Kansas City Chiefs quarterback Patrick Mahomes scrambles out of the pocket against the Dallas Cowboys in the second quarter of their NFL game at Arrowhead Stadium
Kansas City Chiefs quarterback Patrick Mahomes scrambles out of the pocket against the Dallas Cowboys in the second quarter of their NFL game at Arrowhead Stadium GETTY IMAGES NORTH AMERICA via AFP / David Eulitt
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