NFL Thanksgiving Games 2022: Predictions, Odds, Best Bets For Cowboys, Bills, Vikings

There are plenty of options available for anyone who is looking to make bets on the 2022 NFL Thanksgiving games. In addition to the point spreads and over/unders, Thursday's schedule includes team totals and special prop bets.

The Buffalo Bills are favored to beat the Detroit Lions at FanDuel Sportsbook and be the highest-scoring team on Thanksgiving. The New York Giants have the best odds to score the fewest points on the holiday schedule. The Dallas Cowboys and Minnesota Vikings are home favorites.

Here's a look at the Thanksgiving odds, along with a prediction against the spread and a best bet for each Thursday game.

Buffalo Bills (-9.5) at Detroit Lions, 53.5

The Lions are finally meeting preseason expectations during their three-game winning streak. Even if Detroit doesn't upset Buffalo on Thanksgiving, the Lions can be competitive and give the Bills a scare. Detroit has only been defeated by more than one score in two games this season, and both of those losses came on the road.

While still among the most explosive offenses in the league, the Bills haven't been quite as dominant in recent weeks. Buffalo has failed to score more than 31 points in five straight games and seven of the last eight contests. The Lions last gave up more than 31 points in Week 4.

Prediction ATS: Detroit

Best Bet: Buffalo Under 31.5 points

New York Giants (+8.5) at Dallas Cowboys, 44.5

The Cowboys should defeat the Giants at home, but Thursday's line is a little inflated because of Sunday's one-sided results. Dallas isn't as good as it looked in Sunday's 40-3 win over Minnesota. New York should play better than it did in its 31-18 loss at the hands of Detroit.

Micah Parsons finished Sunday's game, though he did suffer a knee injury and might not be completely healthy just a few days later. Eight of the Giants' 10 games have been decided by one score. Saquon Barkley should bounce back against a defense that ranks 27th in opponents' yards per carry.

Prediction ATS: New York

Best Bet: New York +8.5

New England Patriots (+3) at Minnesota Vikings, 41.5

Zach Wilson's awful performance in New England overshadowed the fact that Mac Jones continues to play worse than most starting quarterbacks. In his last four starts, Jones has been on the field for just two offensive touchdowns by the Patriots. New England could be hard-pressed to score enough points to win in one of the toughest environments for visiting teams.

The Vikings could have trouble moving the ball, as well. Left tackle Christian Darrisaw probably won't play because of a concussion. Bill Belichick can do his best to limit Justin Jefferson's targets. Look for Minnesota to win a low-scoring game.

Prediction ATS: Minnesota

Best Bet: Under 41.5