NFL Week 1 Picks Against The Spread 2022: Predictions ATS, Betting Odds

There are 10 home underdogs on the schedule for Week 1 of the 2022 NFL season. No team is favored by more than a touchdown, and four games feature a point spread of less than a field goal.

Here are picks against the spread for every game in Week 1, as well as updated betting odds. These are the latest betting lines from FanDuel and DraftKings Sportsbook.

Buffalo Bills (-2.5) at Los Angeles Rams

The Super Bowl champs shouldn't be underdogs at home, even if the Bills are among the top AFC contenders. Buffalo gave up 42 points in its last game and will miss injured cornerback Tre'Davious White against Cooper Kupp. Since 2014, the defending champs are 6-1 in the NFL's annual Kickoff Game.

Prediction ATS: Los Angeles

Baltimore Ravens (-7) at New York Jets

Prior to losing last season's opener in Las Vegas, Baltimore had won four straight Week 1 matchups by an average margin of 36.3 points per game. With Joe Flacco likely under center for the Jets, the Ravens might be headed for another blowout victory. In three career Week 1 games, Lamar Jackson has nine touchdown passes and no interceptions.

Prediction ATS: Baltimore

Indianapolis Colts (-8) at Houston Texans

Houston might catch Indianapolis off guard and make this game surprisingly close. The Colts are 0-4 in Week 1 games under head coach Frank Reich. Davis Mills didn't start when the Colts blew out the Texans in Houston late last season.

Prediction ATS: Houston

New Orleans Saints (-5.5) at Atlanta Falcons

There are too many questions about the Saints to bet them as 5.5-point road favorites. How effective will Michael Thomas be after two years off the field? How good is the offensive line? Jameis Winston is coming off a torn ACL and didn't even throw for 170 yards per game last season.

Prediction ATS: Atlanta

Pittsburgh Steelers (+6.5) at Cincinnati Bengals

The Bengals won't have an easy time against their AFC North rivals. Cincinnati has a target on its back, following a trip to the Super Bowl. Pittsburgh found a way to upset Buffalo in last year's opener.

Prediction ATS: Pittsburgh

New England Patriots (+3) at Miami Dolphins

Everything is pointing toward Miami being better than New England in 2022. The Dolphins have surrounded Tua Tagovailoa with elite weapons and a much improved offensive line. Mac Jones is without a true No. 1 receiver, and he could take a step back in his sophomore season now that Matt Patricia is the Patriots' de facto offensive coordinator.

Prediction ATS: Miami

Cleveland Browns (+2.5) at Carolina Panthers

Jacoby Brissett can be a fine game manager in Cleveland. Baker Mayfield might eventually find his footing in Carolina, but he's in a tough situation Sunday, making his debut against a good defense that knows him well. The Panthers don't have many quality wins under Matt Rhule.

Prediction ATS: Cleveland

San Francisco 49ers (-7) at Chicago Bears

San Francisco should beat Chicago by at least one touchdown. The 49ers are among the top NFC playoff contenders. The Bears might be headed for the NFL's worst record. Nick Bosa could have his way with maybe the worst offensive line in football.

Prediction ATS: San Francisco

Philadelphia Eagles (-4) at Detroit Lions

The Eagles embarrassed the Lions 44-6 in Detroit last season. Philadelphia is one of the league's most improved teams from last year. Most of the Lions' success should come in the second half of the season when their schedule gets much easier.

Prediction ATS: Philadelphia

Jacksonville Jaguars (+3) at Washington Commanders

Now that Jacksonville has gone from Urban Meyer to a Super Bowl winning head coach, the Jaguars might be as good as the Commanders. Because Washington has arguably the NFL's worst home-field advantage, the line should be closer to one point than a field goal. Trevor Lawrence will be the best quarterback on the field.

Prediction: Jacksonville

New York Giants (+5.5) at Tennessee Titans

The Titans should be favored by a touchdown at home against the Giants. Tennessee isn't getting enough respect after earning the AFC's No.1 seed last season and losing a nail-biter in the playoffs. New York had the NFC's worst offense in 2021 and exhibited few encouraging signs in training camp and the preseason.

Prediction ATS: Tennessee

Las Vegas Raiders (+3.5) at Los Angeles Chargers

While the Chargers are getting all of the preseason hype, it was the Raiders that won the season finale between the AFC West rivals and earned a playoff berth. Davante Adams could have a big debut for Las Vegas with Chargers cornerback J.C. Jackson out with an ankle injury.

Prediction ATS: Las Vegas

Green Bay Packers (-1.5) at Minnesota Vikings

The gap between the Packers and Vikings might've closed with Adams' departure and Minnesota's coaching change. Allen Lazard is uncertain because of an injury, potentially severely limiting Aaron Rodgers' options. Few teams can slow down the Vikings when Kirk Cousins, Justin Jefferson, Adam Thielen and Dalvin Cook are all healthy.

Prediction ATS: Minnesota

Kansas City Chiefs (-3.5) at Arizona Cardinals

Good luck stopping Patrick Mahomes and Kansas City's offense when Andy Reid has months to prepare for an opponent. The Chiefs are 4-0 in Mahomes' Week 1 starts, scoring at least 33 points in each game. Mahomes has 13 touchdown passes, no interceptions and an average 131.4 passer rating in season openers.

Prediction ATS: Kansas City

Tampa Bay Buccaneers (-2) at Dallas Cowboys

Dallas might be able to steal a win Sunday night. Tom Brady could be a little rusty after his preseason hiatus. The Bucs are dealing with offensive line and wide receiver injuries. Dak Prescott threw for 403 yards in Tampa Bay during last year's opener.

Prediction ATS: Dallas

Denver Broncos (-6.5) at Seattle Seahawks

It's a stretch to say that the Broncos are close to 10 points better than the Seahawks on a neutral field in Week 1, which this point spread suggests. Don't just assume that Russell Wilson will be terrific in his return to Seattle. The quarterback could get off to a slow start as he adjusts to a new offense.

Prediction ATS: Seattle