NFL Week 10 Picks Against The Spread 2022: Predictions ATS, Odds, Upset Winners

There are 14 games on the 2022 Week 10 schedule, and six contents feature a betting line of more than six points. The Philadelphia Eagles, Kansas City Chiefs and San Francisco 49ers are the biggest favorites. The Atlanta Falcons, Dallas Cowboys and New Orleans Saints are favored on the road.

Here are picks against the spread for every game in Week 10 and updated betting odds from FanDuel and DraftKings Sportsbook.

Atlanta Falcons (-3) at Carolina Panthers

The Panthers played like a competent team for two games after Matt Rhule's firing, but that was short-lived. P.J. Walker was benched last week in another indication that Carolina has the league's worst quarterback situation. If it wasn't for a Hail Mary to D.J. Moore in the final seconds, the Falcons would've beaten the Panthers by six points in Week 8.

Prediction ATS: Atlanta

Seattle Seahawks (+2.5) vs. Tampa Bay Buccaneers

Because this game is being played at a neutral site in Germany, the betting line suggests that Tampa Bay is clearly the better team. That couldn't be further from the truth, given what has transpired through the first nine weeks. Geno Smith has a 107.2 passer rating and continues to play at a Pro-Bowl level. The Buccaneers have scored more than 22 points just once. The Seahawks should cover the spread and pull off the outright upset.

Prediction ATS: Seattle

Jacksonville Jaguars (+9.5) at Kansas City Chiefs

The Chiefs have developed a habit of winning straight up but not covering the spread. Kansas City just held off Tennessee 20-17 in Week 9 as double-digit favorites. In his last 34 games as a favorite of three points or more, Patrick Mahomes is 12-22 against the spread. Jacksonville hasn't lost a game by more than eight points this season.

Prediction ATS: Jacksonville

Houston Texans (+6.5) at New York Giants

The Giants are in the playoff picture because of their ability to win close games. All six of New York's victories have been decided by one score. Five of those wins have come by six points or fewer. Look for Houston to be competitive and come up short of a victory, which has been the case for most of the Texans' games in 2022.

Prediction ATS: Houston

Detroit Lions (+2.5) at Chicago Bears

If the season started in mid-October, the Bears might be a playoff team. Chicago has figured out the best way to utilize Justin Fields, and it's resulted in the team scoring at least 29 points in three straight games. Detroit gives up more than 29 points per game for the league's worst defense. The Lions won't be as fortunate as they were in Week 9 when Aaron Rodgers threw three interceptions inside the 25-yard line.

Prediction ATS: Chicago

New Orleans Saints (-2.5) at Pittsburgh Steelers

An improving New Orleans defense has climbed its way into the top 11 in yards allowed per game and per play. The Steelers still haven't scored more than 20 points in regulation, and the offense has gotten worse with Kenny Pickett under center. As long as Jameis Winston or Andy Dalton can avoid making back-breaking turnovers, this is a game that the Saints should win.

Prediction ATS: New Orleans

Cleveland Browns (+3.5) at Miami Dolphins

The Dolphins still have a perfect record when Tua Tagovailoa starts and finishes a game. That streak might come to an end the next time Miami faces a team that can keep up with it in the passing game. Cleveland is not that team. Tagovailoa's 115.9 passer rating is the league's best. Tyreek Hill is on pace for the first ever 2,000-yard receiving season.

Prediction ATS: Miami

Minnesota Vikings (+6.5) at Buffalo Bills

Josh Allen's elbow injury is hanging over this game. If the quarterback isn't completely healthy or is forced to sit, the Vikings have a real chance to pull off the outright upset. It hasn't always been pretty, but Minnesota has gone undefeated against teams that don't have a perfect record.

Prediction ATS: Minnesota

Denver Broncos (+3) at Tennessee Titans

If Ryan Tannehill was able to play in Kansas City, the Titans might be on a six-game winning streak. There's a good chance that Tannehill will be back on the field to take on the AFC's most disappointing team. A bye week probably won't do much to help Denver's offense, which is only scoring 15.1 points per game. After the Broncos allowed Travis Etienne Jr. to run for 165 yards in their last game, Derrick Henry is unlikely to be slowed down in Week 10.

Prediction ATS: Tennessee

Indianapolis Colts (+6.5) at Las Vegas Raiders

The Raiders cannot be trusted as 6.5-point favorites, even against this Colts team. This could be one of Indianapolis' best offensive performances of the season, considering Las Vegas has given up at least 20 points to every single opponent. Maybe Indianapolis will surprise Las Vegas in its first game since Frank Reich was fired.

Prediction ATS: Indianapolis

Arizona Cardinals (+3) at Los Angeles Rams

There's a big enough sample size to come to the conclusion that Sean McVay has Kliff Kingsbury's number. In eight head-to-head matchups, the Rams coach has beaten the Cardinals coach seven times. All seven of those wins have come by a touchdown or more. Arizona averages fewer than two sacks per game, so Los Angeles should finally be able to give Matthew Stafford enough protection.

Prediction ATS: Los Angeles

Dallas Cowboys (-5) at Green Bay Packers

The Cowboys have made easy work of the mediocre opponents on their schedule. The Packers fall into the category of mediocre teams, even with the back-to-back MVP at quarterback. Green Bay's 17.1 points per game rank 26th in the league. Rodgers has already surpassed his interception total in each of the last five seasons. Each of the Cowboys' last four wins have come by more than 11 points.

Prediction ATS: Dallas

Los Angeles Chargers (+7) at San Francisco 49ers

Justin Herbert gives the Chargers the clear edge at quarterback. Because of injuries, the 49ers are better in just about every other area. Los Angeles could be without both Keenan Allen and Mike Williams. San Francisco will be incredibly difficult to stop with a healthy Deebo Samuel, George Kittle and Christian McCaffrey in the lineup.

Prediction ATS: San Francisco

Washington Commanders (+11) at Philadelphia Eagles

The Eagles should remain undefeated, but Monday's game could be closer than their Week 3 matchup in Washington. Taylor Heinicke has arguably been better than Carson Wentz. Washington has held five straight opponents to 21 points or fewer. The Commanders were last defeated by more than four points in Week 4.

Prediction ATS: Washington

Season Record: 63-69-4