NFL Week 15 Picks Against The Spread 2021: Predictions ATS, Betting Odds, Matchups

The NFL’s biggest favorites have been dominant in recent games. Teams laying at least a touchdown are 11-0 against the spread over the last two weeks. Six underdogs are getting more than eight points on Sunday’s schedule.

Here are picks against the spread for every game in Week 15 of the 2021 season, as well as updated betting odds. Betting lines come from FanDuel Sportsbook.

Kansas City Chiefs (-4) at Los Angeles Chargers

Los Angeles defeated Kansas City 30-24 earlier this season. Justin Herbert has thrown eight touchdowns and one interception for a 117.9 passer rating in three career starts against the Chiefs. The Chargers are 3-1 against the spread as underdogs.

Prediction ATS: Los Angeles

Las Vegas Raiders (+5.5) at Cleveland Browns

The way Cleveland’s offense has played for two months, the Browns might have trouble beating any halfway decent team by a touchdown. Just once in the last eight games has Cleveland scored at least 25 points or won by more than a field goal.

Prediction ATS: Las Vegas

New England Patriots (+2.5) at Indianapolis Colts

The Patriots are a better team than the Colts, and they are a perfect 6-0 on the road. Indianapolis is 1-4 when scoring fewer than 26 points. New England has surrendered 25 points or fewer in nine of the last 10 games. Bill Belichick and the Patriots’ top-ranked scoring defense will force Carson Wentz to try and beat them.

Prediction ATS: New England

Dallas Cowboys (-10.5) at New York Giants

Ever since Dak Prescott suffered a calf injury in Week 6, the Cowboys’ offense hasn’t been quite right. Prescott has posted a sub-80.0 passer rating in four of his last six starts. New York’s defense, which has given up a 91.0 passer rating, can help keep this within 10 points.

Prediction ATS: New York

Houston Texans (+3.5) at Jacksonville Jaguars

Jacksonville absolutely shouldn’t be favored by more than a field goal against anyone. It’s Week 15, and the Jaguars still haven’t scored more than 23 points in any game this season. All of the controversy surrounding Urban Meyer doesn't help Jacksonville’s case.

Prediction ATS: Houston

Tennessee Titans (-1.5) at Pittsburgh Steelers

It’s hard to know what to make of Tennessee right now. The Titans remain in contention for the No. 1 seed while they deal with a historically injured roster. Tennessee’s offense hasn’t been responsible for more than 23 points in any game since Derrick Henry underwent foot surgery.

Prediction ATS: Pittsburgh

Arizona Cardinals (-13.5) at Detroit Lions

This is the perfect spot for the Cardinals to get back on track, following Monday night’s loss against the Rams. Arizona has won all seven of its road games by double digits. The Lions have scored fewer than 17 points in five of the last six games.

Prediction ATS: Arizona

Carolina Panthers (+10.5) at Buffalo Bills

As long as Josh Allen’s turf toe doesn’t affect his play too much, the Bills should rout the Panthers. Carolina has lost 11 straight games started by Cam Newton. All seven of Buffalo’s wins have come by more than 14 points.

Prediction ATS: Buffalo

New York Jets (+8.5) at Miami Dolphins

Miami’s offense makes it difficult to pick the Dolphins as two-score favorites. The Dolphins are second to last in yards per play, putting them eight spots behind the Jets. New York kept its last matchup against Miami within a touchdown.

Prediction ATS: New York

Washington Football Team (+4.5) at Philadelphia Eagles

It’s probably best to take the underdog in this matchup of mediocre NFC East teams. The knee injury that sidelined Taylor Heinicke in Week 14 isn’t expected to keep the quarterback off the field Sunday. Washington went 2-0 against Philadelphia last season.

Prediction ATS: Washington

Cincinnati Bengals (+1) at Denver Broncos

Cincinnati is the type of team that Denver has played well against in 2021. Six of the Broncos’ seven wins have come against opponents that rank in the bottom half of the league in yards per play allowed. The Bengals are 19th in that category and 29th in pass defense.

Prediction ATS: Denver

Atlanta Falcons (+8.5) at San Francisco 49ers

In five games against teams that are in the Week 15 playoff picture, Atlanta is 0-5. The Falcons have lost those games by an average score of 36-15. The Seahawks are the only team outside of the latest playoff bracket that has beaten the 49ers.

Prediction ATS: San Francisco

Green Bay Packers (-4.5) at Baltimore Ravens

Even if Lamar Jackson is back under center for Baltimore, Green Bay is simply the much better team. While Jackson has struggled with 16 touchdowns and 13 interceptions two seasons after winning the MVP award, Aaron Rodgers is a top-two candidate to repeat as the MVP. The Packers are averaging 37.3 points in the last three games. The Ravens last scored more than 22 points in Week 9.

Prediction ATS: Green Bay

Seattle Seahawks (+6.5) at Los Angeles Rams

The line is too high, given how much better Russell Wilson has played in the last two games. Wilson has posted an average passer rating of 108.4 in the last three contests. Seattle last gave up more than 23 points in a game on Oct. 5.

Prediction ATS: Seattle

New Orleans Saints (+10.5) at Tampa Bay Buccaneers

No team has played Tom Brady better since he joined Tampa Bay than New Orleans. The Saints are 3-0 against Brady’s Bucs in the regular season, forcing him to throw multiple interceptions in each game. New Orleans has scored at least 34 points in all of those matchups, including when Trevor Siemian took the majority of snaps in a 36-27 Week 8 victory.

Prediction ATS: New Orleans

Minnesota Vikings (-4) at Chicago Bears

Virtually every Minnesota game goes down to the wire, and Monday night’s contest might not be any different. The Bears are 5-1 in their last six matchups with the Vikings. Justin Fields is averaging 74 rushing yards in his last three full games.

Prediction ATS: Chicago

Season Record: 100-105-3