NFL Week 15 Picks Against The Spread 2022: Predictions ATS, Odds, Upset Winners

There are no more byes in the 2022 NFL regular season, making for a 16-game Week 15 schedule. Four teams are favored by at least a touchdown. Two games feature a spread of just a single point.

Here are picks against the spread for every game in Week 15 and updated betting odds from FanDuel and DraftKings Sportsbook.

San Francisco 49ers (-3.5) at Seattle Seahawks

The injury to Deebo Samuel and the hook probably make the Seahawks the right pick against the spread. Seattle might not be able to pull off the outright upset, but they should be able to be competitive in a key divisional matchup. Let's see how Brock Purdy plays in his first road start in a hostile environment.

Prediction ATS: Seattle

Indianapolis Colts (+4) at Minnesota Vikings

The Colts might be one of the few teams that won't be able to take advantage of a reeling Vikings defense. Indianapolis has scored fewer than 20 points in every game during its three-game losing streak. The Vikings are 5-1 in Minnesota, and all those victories have come by more than a field goal.

Prediction ATS: Minnesota

Baltimore Ravens (+3) at Cleveland Browns

Deshaun Watson has simply been bad since his return from a nearly two-year hiatus. Cleveland's quarterback has completed 59.4% of his passes for 407 yards, one touchdown and an interception. Even with a third-string quarterback under center, the Ravens can make this a typical, close AFC North matchup, and possibly upset the Browns.

Prediction ATS: Baltimore

Miami Dolphins (+7.5) at Buffalo Bills

The Dolphins were fortunate to upset the Bills in Week 3 when Buffalo outgained Miami by 285 yards. If Tyreek Hill's ankle injury slows the receiver down at all, Tua Tagovailoa could be in for another rough game. Tagovailoa has completed 45.9% of his passes in back-to-back losses. Buffalo has held opposing quarterbacks to an 81.7 passer rating.

Prediction ATS: Buffalo

Philadelphia Eagles (-8.5) at Chicago Bears

It might take a meaningless touchdown, but the Bears have a chance to keep this within a touchdown after last week's bye. Justin Fields is averaging 101.6 rushing yards in his last seven games and can engineer a late drive for a backdoor cover. Maybe Philadelphia will look past Chicago as it cruises toward a first-round bye.

Prediction ATS: Chicago

Pittsburgh Steelers (+2.5) at Carolina Panthers

It's probably time to fade the Panthers. Carolina has won three out of four games, averaging 26.0 points in the victories. Pittsburgh has given up fewer than 21 points in five of the six games that T.J. Watt has played. The Steelers are ninth in opponents' yards per carry. If Pittsburgh forces Sam Darnold to make important throws, the Steelers should win outright.

Prediction ATS: Pittsburgh

Atlanta Falcons (+4.5) at New Orleans Saints

In what might be the worst game on the Week 15 schedule, taking the points is the best option. A change at quarterback might only help the Falcons. Both the Saints and Falcons have scored 17 points or fewer in four of the last five games.

Prediction ATS: Atlanta

Dallas Cowboys (-4.5) at Jacksonville Jaguars

It's been a long time since the Jaguars have been able to string together two straight good games. The last time Jacksonville faced a top-10 defense, it was held to 17 points in a loss against Denver. Dak Prescott should bounce back from an unusually poor game in Houston. The Cowboys are going to take the Jaguars seriously after nearly being upset by the Texans.

Prediction ATS: Dallas

Detroit Lions (-1) at New York Jets

As long as Mike White is healthy enough to start, the Jets shouldn't be underdogs at home in Week 15. New York's defense continues to impress, holding Josh Allen to 194 yards of offense in a 20-12 defeat. The Lions are 0-3 on the road in their three toughest away games.

Prediction ATS: New York

Kansas City Chiefs (-14) at Houston Texans

The Texans covered the spread last week as the biggest underdogs of the season. The Chiefs won outright but lost against the spread as big favorites in Denver. Houston has only lost one game by more than two scores.

Prediction ATS: Houston

Arizona Cardinals (+2.5) at Denver Broncos

The Broncos might have the better quarterback for one of the few times this season. When Colt McCoy started against San Francisco's No. 1 ranked defense earlier this season, Arizona was blown out 38-10. The Cardinals will have trouble scoring more points against the Broncos' No. 4 ranked scoring defense.

Prediction ATS: Denver

New England Patriots (-1) at Las Vegas Raiders

If anyone is familiar with Josh McDaniels' offense and how to stop it, it's Bill Belichick. Belichick's defenses are known for taking away the opponent's strength. Davante Adams is Las Vegas' best player. The Raiders are 0-4 in the games during which Davante Adams has recorded his four-lowest receiving totals.

Prediction ATS: New England

Tennessee Titans (+2.5) at Los Angeles Chargers

Tennessee will have trouble keeping up with a Los Angeles offense that is finally healthy. The Chargers can put up points with just about anyone when Justin Herbert, Keenan Allen and Mike Williams are all on the field. The Titans have scored fewer than 23 points in eight of the last nine games.

Prediction ATS: Los Angeles

Cincinnati Bengals (-3.5) at Tampa Bay Buccaneers

The Buccaneers are lucky to be atop the NFC's weakest division. Since beating Dallas in the season opener, Tampa Bay hasn't defeated a single team that is in the Week 15 playoff picture. Joe Burrow is playing like a top-three quarterback, leading the Bengals to five straight wins, four of which have come by more than a field goal.

Prediction ATS: Cincinnati

New York Giants (+4.5) at Washington Commanders

Washington should be favored at home, but the point spread has gotten too high. Expect another low-scoring, ugly NFC East match. The rivals played to a tie in Week 13. Four of their last five meetings have been decided by three points or fewer.

Predictions ATS: New York

Los Angeles Rams (+7) at Green Bay Packers

Even against the injury-riddled Rams team, it's hard to feel good about picking the Packers as seven-point favorites. Baker Mayfield did lead Los Angeles to a comeback victory in his Rams debut. Since Week 3, the Packers have beaten one opponent by more than a field goal.

Prediction ATS: Los Angeles

Season Record: 101-103-4