Only four teams are favored on the road in Week 2 of the NFL season. Five games feature a point spread of greater than a touchdown. Four of those favorites are coming off Week 1 losses.

Here are picks against the spread for every game in Week 2 and updated betting odds from FanDuel and DraftKings Sportsbook.

Los Angeles Chargers (+3.5) at Kansas City Chiefs

The Chiefs seem to be just about as unstoppable as ever without wide receiver Tyreek Hill. Quarterback Patrick Mahomes had five touchdown passes and a 144.2 passer rating in Week 1. The Chargers could be without wide receiver Keenan Allen and cornerback J.C. Jackson in Kansas City's home opener.

Prediction ATS: Kansas City

New York Jets (+6) at Cleveland Browns

Most of Cleveland's wins with Jacoby Brissett under center are likely to be close games. The quarterback threw for only 147 yards in Week 1. The Browns will rely on their ground game to move the ball. Maybe the Jets' run defense can surprise teams this season. New York limited Baltimore to 63 yards on 21 carries.

Prediction ATS: New York

Washington Commanders (+2.5) at Detroit Lions

This game is essentially a toss-up. Quarterback Carson Wentz had a rollercoaster performance in his Washington debut, throwing four touchdowns and a pair of interceptions. Detroit's defense surrendered the second-most points and the third-most yards in Week 1.

Prediction ATS: Washington

Tampa Bay Buccaneers (-3) at New Orleans Saints

Tom Brady is 0-4 against the Saints as the Buccaneers quarterback in the regular season. Tampa Bay only scored 19 points in Week 1. Chris Godwin is expected to miss Week 2 with a hamstring injury, and the Bucs' offensive line suffered another injury when left tackle Donovan Smith hyperextended his right elbow.

Prediction ATS: New Orleans

Carolina Panthers (+2.5) at New York Giants

The Giants are going to need one more win before they can be taken seriously as a much-improved team. Carolina's Baker Mayfield is the better quarterback in this game. Giants quarterback Daniel Jones was sacked five times and had two turnovers in Week 1. New York was shut out in the first half after posting the NFC's worst offense a season ago.

Prediction ATS: Carolina

New England Patriots (-1.5) at Pittsburgh Steelers

New England shouldn't be favored in Pittsburgh, even with T.J. Watt sidelined. Many of the preseason fears about the Patriots were realized in their 20-7 loss in Miami. Mac Jones is banged up after suffering a back injury. He'll face a Pittsburgh defense that picked off Joe Burrow four times.

Prediction ATS: Pittsburgh

Indianapolis Colts (-4) at Jacksonville Jaguars

The Colts last won in Jacksonville eight years ago. Indianapolis needed a 17-point, fourth-quarter comeback just to tie the Texans in Week 1. Jacksonville showed signs of improvement in Washington and should be able to keep this game within a field goal, at the very least.

Prediction ATS: Jacksonville

Miami Dolphins (+3.5) at Baltimore Ravens

Both teams are coming off two-score victories over AFC East opponents. Let's see how Tua Tagovailoa plays against Baltimore's pass defense. Lamar Jackson has a 38-12 career record as the Ravens starting quarterback.

Prediction ATS: Baltimore

Atlanta Falcons (+10.5) at Los Angeles Rams

With 10 days off and a mediocre opponent, the Rams are in a perfect spot to bounce back from an embarrassing season-opening loss. They just might have a difficult time doing it with a victory of more than 10 points. The Falcons blew a 16-point lead in their home opener.

Prediction ATS: Atlanta

Seattle Seahawks (+8.5) at San Francisco 49ers

The concern level for the 49ers is greater than other teams that were projected to be Super Bowl contenders and lost in Week 1. Trey Lance is an unproven quarterback who has completed just 54.5% of his career passes. Geno Smith, conversely, just went 23-of-28 in Monday night's victory. Seattle's win over Denver might be a sign that the Seahawks could be frisky this season.

Prediction ATS: Seattle

Cincinnati Bengals (-7) at Dallas Cowboys

Dallas is in big trouble without Dak Prescott for the next few weeks. When Prescott was on the field in Week 1, the Cowboys had trouble moving the ball because of their unproven wide receivers. Burrow should bounce back from his five-turnover performance.

Prediction ATS: Cincinnati

Houston Texas (+10) at Denver Broncos

It's hard to trust the Broncos as double-digit favorites. Nathaniel Hackett seemed over his head in his first game as a head coach. The Texans have been an average team over a five-game stretch, going 2-2-1 since Week 15 of last season.

Prediction ATS: Houston

Arizona Cardinals (+6) at Las Vegas Raiders

This point spread has nearly doubled since the start of the week. The Cardinals might not be very good right now, but the line has probably gotten too high. The Raiders have their own issues following a 24-19 loss to the Chargers.

Prediction ATS: Arizona

Chicago Bears (+10) at Green Bay Packers

Aaron Rodgers didn't have much help in Week 1, and the case could be the same for Week 2. Both Green Bay starting tackles could be out for a second straight game. The Packers don't have a proven No. 1 receiver. Rodgers should beat the Bears, which he usually does, but a double-digit win might not be in the cards.

Prediction ATS: Chicago

Tennessee Titans (+9.5) at Buffalo Bills

It might be smart to keep picking the Bills until they fail to cover the spread. Buffalo managed to exceed lofty expectations as Super Bowl favorites with a dominant win over the Rams in the Kickoff Game. Josh Allen has totaled at least 354 yards and four touchdowns in three straight games. In all five of Tennessee's defeats last season, the Titans lost against the spread.

Prediction ATS: Buffalo

Minnesota Vikings (+1.5) at Philadelphia Eagles

This is the toughest game to predict on the Week 2 schedule. Both teams might be headed for division titles. Justin Jefferson gives Minnesota the best player in Monday's game. The star receiver could be the difference-maker in a Vikings' victory.

Prediction ATS: Minnesota

Season Record: 9-7

Mitch Trubisky, Pittsburgh Steeler
Mitch Trubisky #10 of the Pittsburgh Steelers warms up before a preseason game against the Seattle Seahawks at Acrisure Stadium on August 13, 2022 in Pittsburgh, Pennsylvania. Justin Berl/Getty Images