Six of the 16 games in Week 4 of the 2021 NFL season feature a betting total north of 50. Some of the league’s best offenses are set to face top defenses. The prime-time games are expected to be relatively high-scoring.

Here are the five best over/under bets for Week 4. Betting odds come from FanDuel Sportsbook.

Jacksonville Jaguars at Cincinnati Bengals Over 46.5

Thursday night’s game could be more exciting than anticipated. Joe Burrow and Ja’Marr Chase have already linked up for four touchdowns. The duo could combine for a few more scores against the Jaguars, who have allowed a 111.6 passer rating and 30.7 points per game. Trevor Lawrence’s penchant for throwing interceptions could result in points, as well.

New York Giants at New Orleans Saints Under 43.5

The Giants have scored 14 points or fewer in two of their three games. The Saints are only giving up 14 points per game. Darius Slayton and Sterling Shepard both suffered hamstring injuries in Week 3. Jameis Winston still doesn’t have a 150-yard passing game in 2021.

Pittsburgh Steelers at Green Bay Packers Under 45.5

Between Ben Roethlisberger and a mediocre offensive line, the Steelers can’t move the ball down the field. Matt Ryan is the only non-rookie quarterback with a worse QBR than Roethlisberger. The Packers have given up only 206 passing yards per game. Pittsburgh’s defense is getting healthier with T.J. Watt and Alex Highsmith back at practice.

Baltimore Ravens at Denver Broncos Under 44.5

The Broncos rank near the top of the NFL in just about every major defensive category, allowing a league-low 8.7 points per game. An elite secondary should shut down a disappointing Ravens’ receiving corps. Denver has receiving issues of its own with injuries to K.J. Hamler and Jerry Jeudy. No Broncos’ game has featured more than 40 total points.

Las Vegas Raiders at Los Angeles Chargers Over 52.5

This should be a high-scoring AFC West battle. Derek Carr and Justin Herbert rank first and fourth, respectively, in passing yards among all quarterbacks. The Raiders and Chargers totaled at least 57 points in both of their matchups last season. Las Vegas has scored at least 25 points in eight straight games.

Season Record: 9-6

Joe Burrow
Joe Burrow #9 of the Cincinnati Bengals looks to pass the ball against the Los Angeles Chargers during the game at Paul Brown Stadium on September 13, 2020 in Cincinnati, Ohio. Getty Images

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