Underdogs are 38-26 against the spread in the 2021 NFL season and have yet to have a losing week. Four 3-1 teams are getting points in Week 5. Four one-win teams are favored on the upcoming schedule.

Here are picks against the spread for every game in Week 5, as well as updated betting odds. Betting lines come from FanDuel Sportsbook.

Los Angeles Rams (-1.5) at Seattle Seahawks

Russell Wilson leads all quarterbacks with a 129.9 passer rating and has yet to throw an interception. Wilson is terrific in primetime, including a 9-1 record in Thursday night games. Los Angeles’ defense has been a disappointment, giving up just one fewer point than Seattle.

Prediction ATS: Seattle

New York Jets (+3) at Atlanta Falcons (London)

Betting the Falcons as three-point favorites away from Atlanta isn’t the smartest decision. New York’s offense was much improved in Week 4 when it finally didn’t face a top-five defense. The Falcons are giving up an NFL-worst 32.0 points per game.

Prediction ATS: New York

Philadelphia Eagles (+3.5) at Carolina Panthers

Carolina is a level below the top contenders in the NFC, but they should continue to beat the lesser opponents on their schedule. The Panthers rank third in total defense. Philadelphia has gone 0-3 and been outscored by 38 points since beating Atlanta in the opener.

Prediction ATS: Carolina

Miami Dolphins (+10.5) at Tampa Bay Buccaneers

Tampa’s secondary is so banged-up that it could be difficult for the defending champs to win by multiple touchdowns. This game could look similar to Miami’s 27-17 loss against Indianapolis last week.

Prediction ATS: Miami

New Orleans Saints (-1.5) at Washington Football Team

The Saints are the league’s most difficult team to figure out with a couple of blowout wins and a pair of losses as favorites on their resume. Washington has yet to beat a good team this season.

Prediction ATS: New Orleans

Tennessee Titans (-4) at Jacksonville Jaguars

The Jaguars are a complete mess. The team has lost 19 straight games, and now Urban Meyer has become a distraction because of his actions away from the field. If the Titans can get Julio Jones back for this matchup, Tennessee should win by a touchdown.

Prediction ATS: Tennessee

Detroit Lions (+7.5) at Minnesota Vikings

Kirk Cousins has never lost to the Lions as a member of the Vikings. Minnesota is 6-1 against the spread in its last seven matchups with Detroit. During the Lions’ eight-game losing streak, Detroit has lost all three of its road games by double digits.

Prediction ATS: Minnesota

Denver Broncos (+1.5) at Pittsburgh Steelers

Even before Teddy Bridgewater left last game with a concussion, Denver’s offense was struggling mightily. Without two of their top receivers and Drew Lock potentially getting the start under center, the Broncos will have more trouble finding the end zone in Pittsburgh. The Steelers can win a low-scoring game at home.

Prediction ATS: Pittsburgh

Green Bay Packers (-3) at Cincinnati Bengals

Can the Bengals compete with a top Super Bowl contender like the Packers? Cincinnati’s three wins have come against opponents who have a combined 2-10 record. Aaron Rodgers has been brilliant since Green Bay’s Week 1 disaster.

Prediction ATS: Green Bay

New England Patriots (-9) at Houston Texans

The Patriots should take care of business in Houston, but they aren’t exactly built to beat teams by 10 points or more. New England is one of six teams that average fewer than 18.0 points per game. If Davis Mills can avoid throwing several interceptions, the Texans can cover the spread.

Prediction ATS: Houston

Chicago Bears (+5.5) at Las Vegas Raiders

Las Vegas should bounce back after suffering its first loss of the season. Justin Fields and the Bears can’t keep pace with Derek Carr and the Raiders, who boast a top five offense.

Prediction ATS: Las Vegas

Cleveland Browns (+1) at Los Angeles Chargers

The Chargers have played as well as any AFC team through four weeks. They should probably be favored by close to a field goal against a team traveling across the country to play in Los Angeles. Baker Mayfield and Odell Beckham still don’t seem to be on the same page. Justin Herbert is the best quarterback in this game.

Prediction ATS: Los Angeles

New York Giants (+7) at Dallas Cowboys

Daniel Jones has actually been very good this season, throwing just one interception on a Hail Mary attempt while losing no fumbles since the season opener. New York can stay competitive with Dallas. Ultimately, the Cowboys are the top team in the NFC East and should win this game at home. Dak Prescott is an early MVP candidate.

Prediction ATS: New York

San Francisco 49ers (+5.5) at Arizona Cardinals

The line has moved four points in Arizona’s direction over the last two days. That’s too much of a change based on one week’s results and the injury to Jimmy Garoppolo. There still probably isn’t a ton of separation between all four NFC West teams.

Prediction ATS: San Francisco

Buffalo Bills (+3) at Kansas City Chiefs

No matter what the records say, the Chiefs are still the team to beat in the AFC. Buffalo has taken advantage of a weak schedule to start the year. Let’s see how the Bills’ No. 1 ranked defense performs against Patrick Mahomes. Kansas City easily took care of Buffalo in the 2021 AFC Championship Game 38-24.

Prediction ATS: Kansas City

Indianapolis Colts (+7) at Baltimore Ravens

It took facing a backup quarterback and the league’s worst offense in terms of yards per play for the Colts to get their first win. Carson Wentz will struggle against a Ravens’ defense that has allowed 24 total points in the last two games. Baltimore is an overtime loss in Las Vegas away from being undefeated.

Prediction ATS: Baltimore

Season Record: 31-32-1

Patrick Mahomes Chiefs Bills
Darryl Johnson #92 of the Buffalo Bills dives to try and tackle Patrick Mahomes #15 of the Kansas City Chiefs as he looks to throw a pass during the second half at Bills Stadium on October 19, 2020 in Orchard Park, New York. Timothy T Ludwig/Getty Images

RELATED STORIES