Week 7 features several big home favorites. Seven home teams are favored by at least 6.5 points. The two teams that own the best records against the spread for the 2022 NFL season are both underdogs on the upcoming schedule.

Here are picks against the spread for every game in Week 7 and updated betting odds from FanDuel and DraftKings Sportsbook.

New Orleans Saints (+1.5) at Arizona Cardinals

Arizona's offense gets a much-needed boost from the return of DeAndre Hopkins. Road teams are averaging 14.0 points per game in the last four "Thursday Night Football" matchups.

Prediction ATS: Arizona

Detroit Lions (+7) at Dallas Cowboys

The Lions have one of the few offensive lines that might be able to neutralize the Cowboys' vaunted pass rush. Jared Goff has only been sacked seven times. Dallas hasn't scored more than 25 points in any game. It's unknown how effective Dak Prescott will be in his return from thumb surgery.

Prediction ATS: Detroit

Indianapolis Colts (+2.5) at Tennessee Titans

The Titans have won four straight games against the Colts, including a 24-17 victory in Week 4. Tennessee entered its Week 6 bye on a three-game winning streak. The Titans have never lost after a bye in the regular season with Mike Vrabel as their head coach,

Prediction ATS: Tennessee

New York Giants (+3) at Jacksonville Jaguars

After beating the Packers and Ravens in back-to-back games to improve to 5-1 on the season, the Giants should arguably be favored in Jacksonville. The Jaguars have lost three straight games by at least seven points. The Giants haven't given up more than 23 points in any game.

Prediction ATS: New York

Cleveland Browns (+6.5) at Baltimore Ravens

These teams have played close games all season, and that will probably be the case in their upcoming divisional matchup. Three of Cleveland's four losses have come by a field goal or less. Since the season opener, Baltimore only has one victory by more than two points.

Prediction ATS: Cleveland

Atlanta Falcons (+6.5) at Cincinnati Bengals

It's probably time to start taking the Falcons seriously as a playoff contender. Atlanta has won three of its last four games with the league's No. 3 rushing offense. The Falcons are the only team left that is perfect against the spread.

Prediction ATS: Atlanta

Green Bay Packers (-5.5) at Washington Commanders

Green Bay is struggling to score points, but Washington's offense is significantly worse. The Commanders have a bottom-five scoring offense and are now down to a backup quarterback.

Prediction ATS: Green Bay

Tampa Bay Buccaneers (-11) at Carolina Panthers

Can the Bucs beat any team by more than 10 points right now? Tampa Bay has scored 21 points or fewer in five of its six games. The team's offensive line has clearly affected the play of Tom Brady, who has thrown exactly one touchdown pass in five games.

Prediction ATS: Carolina

Houston Texans (+7) at Las Vegas Raiders

The Raiders have an even worse record than the Texans because of key mistakes that they've made down the stretch of most games this season. Las Vegas should pull out a victory, but it probably won't be by more than one score. Houston has only lost one game by more than seven points.

Prediction ATS: Houston

New York Jets (+2.5) at Denver Broncos

Denver has been the biggest disappointment of the 2022 season, while New York has been one of the most pleasant surprises. The Broncos are dead-last in scoring. Russell Wilson is putting up the worst stats of his career, and he isn't getting much help from his receivers or offensive line.

Prediction ATS: New York

Seattle Seahawks (+6.5) at Los Angeles Chargers

The Chargers' defense isn't fixed just because they held the league's lowest-scoring team to 16 points in Week 6. Los Angeles gives up the most yards per carry. Seattle is fourth in yards per carry. Geno Smith hasn't thrown an interception in three straight games.

Prediction ATS: Seattle

Kansas City Chiefs (-3) at San Francisco 49ers

A rash of injuries finally caught up with the 49ers in their Week 6 loss against the Falcons. It will be hard for San Francisco to keep pace with Kansas City if the team isn't at full strength. The 49ers have scored fewer than 15 points in half their games.

Prediction ATS: Kansas City

Pittsburgh Steelers (+7) at Miami Dolphins

Miami went 3-0 in Tua Tagovailoa's first three starts, defeating all playoff contenders. The team has gone winless since Tagovailoa suffered a concussion, but the quarterback is likely to return and help the Dolphins get back into the win column Sunday night. The Steelers have failed to score more than 20 points in regulation in nine of their last 10 games.

Prediction ATS: Miami

Chicago Bears (+7.5) at New England Patriots

These teams are headed in opposite directions. The Bears are on a three-game losing streak, during which they are scoring just 13.7 points per game. Chicago's offense is in for a long night against Bill Belichick's defense. The Patriots have given up 15 total points in their two game-winning streak.

Prediction ATS: New England

Season Record: 42-50-2

Ezekiel Elliott Dallas Cowboys
Ezekiel Elliott #21 of the Dallas Cowboys runs against the Arizona Cardinals during the second quarter at AT&T Stadium on October 19, 2020, in Arlington, Texas. Ronald Martinez/Getty Images