NFL Week 8 Picks Against The Spread 2021: Predictions ATS, Betting Odds, Matchups

With 15 games on the NFL Week 8 schedule, 10 matchups feature a betting line of more than a field goal. Three teams in the latest NFC playoff picture are underdogs. Every AFC playoff team is favored.

Here are picks against the spread for every game in Week 8 of the 2021 NFL season, as well as updated betting odds. Betting lines come from FanDuel Sportsbook.

Green Bay Packers (+6) at Arizona Cardinals

The line has moved 2.5 points toward Arizona in light of the news that Green Bay will likely be without defensive coordinator Joe Barry and star receiver Davante Adams, both of whom reportedly tested positive for COVID-19. That’s probably too big of a change with Aaron Rodgers still under center for a 6-1 team. The Packers managed to go 3-0 when Adams was sidelined last season.

Prediction ATS: Green Bay

Miami Dolphins (+13.5) at Buffalo Bills

Sean McDermott and the Bills own Brian Flores and the Dolphins. Buffalo has a six-game winning streak against Miami with an average margin of victory of 20 points. The Bills are 3-0 against sub.-500 teams, winning by an average score of 39-7. The Dolphins have not won since the season opener.

Prediction ATS: Buffalo

Carolina Panthers (+3) at Atlanta Falcons

Matt Ryan gives Atlanta the much better quarterback, considering Sam Darnold’s struggles. Darnold's troubles with the Jets have spilled over in his time with the Panthers, throwing more interceptions than touchdowns. The Panthers are on a four-game losing streak. The Falcons have won three of their last four games.

Prediction ATS: Atlanta

Philadelphia Eagles (-3.5) at Detroit Lions

The Lions managed to give the Rams a game in Week 7 as they fell to 0-7 on the season. Detroit has largely been competitive, going 4-3 against the spread. Philadelphia is 1-5 in its last six games with the only victory being a comeback, three-point win against Carolina. The Lions can keep this within a field goal and potentially, finally, steal a victory.

Prediction ATS: Detroit

Tennessee Titans (-1.5) at Indianapolis Colts

The Titans are the class of the AFC South, and they can essentially put the division race to rest with a win Sunday. Tennessee looks like a true Super Bowl contender with consecutive wins over the Bills and Chiefs. The Colts are 0-3 against teams with winning records, including a nine-point loss in Tennessee.

Prediction ATS: Tennessee

Los Angeles Rams (-14.5) at Houston Texans

There’s a good chance Tyrod Taylor will be back under center for Houston. The Texans were competitive before Taylor got hurt, easily beating the Jaguars and covering the spread in Cleveland. Houston can keep this within two sores at home.

Prediction ATS: Houston

Cincinnati Bengals (-10.5) at New York Jets

Two things are clear after Week 7: the Bengals are for real, and the Jets’ one victory was a fluke. New York’s offense isn’t going to be fixed with Joe Flacco or Mike White at quarterback. The Bengals haven’t given up more than 25 points to anyone, so the Jets might be lucky to even reach the 17-point mark.

Prediction ATS: Cincinnati

Pittsburgh Steelers (+3.5) vs. Cleveland Browns

Cleveland doesn’t exactly have a great choice at quarterback between Case Keenum and Baker Mayfield with one good shoulder. Pittsburgh’s defense could have a big day against a Browns’ offense that is still dealing with injuries. The Steelers averaged 32.3 points in three games against the Browns last season.

Prediction ATS: Pittsburgh

San Francisco 49ers (-3.5) Chicago Bears

It’s hard to believe the Bears have found a way to win three games. Chicago’s offense is awful. In five starts, Justin Fields has two touchdowns and five interceptions while averaging just 149.2 passing yards per game. San Francisco’s defense will give the offense short fields to work with, allowing Jimmy Garoppolo to lead the 49ers on a few touchdown drives.

Prediction ATS: San Francisco

Jacksonville Jaguars (+3) at Seattle Seahawks

The Jaguars are coming off a bye, while the Seahawks have a short week after losing Monday night. Trevor Lawrence is playing better than Geno Smith, who has been sacked 10 times with just 376 passing yards in two starts. Jacksonville won its last game and nearly beat the No. 1 seed Bengals a few weeks ago. Seattle’s conservative approach makes it difficult for the team to win, let alone beat anyone by more than a field goal.

Prediction ATS: Jacksonville

New England Patriots (+5.5) at Los Angeles Chargers

Aside from their Week 3 loss against the Saints, the Patriots have either won or lost by a small margin every week. Mac Jones has only had one bad performance, posting four triple-digit passer ratings and six games with a rating of at least 89.0. Los Angeles has a more explosive offense and will probably win a close contest.

Prediction ATS: New England

Washington Football Team (+3) at Denver Broncos

Because this is a coin-flip game between two bad teams, grabbing the points with Washington is the best bet. Washington has been taken care of by the toughest opponents on its schedule, but the team did beat the Falcons and Giants. The Broncos have fallen apart with four straight losses, and their defense is very banged up, particularly in the front seven.

Prediction ATS: Washington

Tampa Bay Buccaneers (-5) at New Orleans Saints

The Saints will likely struggle to keep up with the Bucs’ offense. Jameis Winston’s 185.7 passing yards per game are the lowest among quarterbacks with at least six starts. New Orleans ranks 27th in yards per play. Tampa Bay is second in total offense and third with 33.3 points per game. Tom Brady leads the league with 2,275 passing yards and 21 touchdowns.

Prediction ATS: Tampa Bay

Dallas Cowboys (-2.5) at Minnesota Vikings

Minnesota finds ways to lose against good teams. Dallas might be as good as anyone in the NFC, going on a five-game winning streak after losing a nail-biter to Tampa Bay in the opener. Minnesota’s pass rush will be neutralized by the Cowboys’ offensive line and the top-ranked unit in football.

Prediction ATS: Dallas

New York Giants (+10) at Kansas City Chiefs

The Chiefs are playing so poorly that they probably shouldn’t be double-digit favorites against any team that has more than one win. Kansas City is one of only four teams that is allowing more than 400 yards and at least 29 points per game. If the Giants get a couple of their injured playmakers back on the field, they can keep this within a touchdown.

Prediction ATS: New York

Season Record: 50-54-3