Obesity: Reverse This Complex Disease By Having 2 Glasses Orange Juice Everyday

Obesity is on the rise in the U.S. and, according to the recent data, adult obesity rates in the nation exceed 35%. A new study pointed out that orange juice can be an impactful source in reversing obesity.

Per the new research, a unique molecule called nobiletin present in orange juice can dramatically reverse negative obesity-induced outcomes and even decrease one’s risk of developing health conditions including heart diseases and diabetes.

“Obesity, dyslipidemia, and insulin resistance, the increasingly common metabolic syndrome, are risk factors for CVD and type 2 diabetes that warrants novel therapeutic interventions,” the Ladders quoted the study’s authors. “In mice fed a high-fat diet, nobiletin robustly prevented obesity, hepatic steatosis, dyslipidemia, and insulin resistance, and it improved energy expenditure. These studies further underscore the therapeutic potential of nobiletin and begin to clarify possible mechanisms.”

Although nobiletin was initially presumed to be involved in pathways pertaining to energy conversion, further analysis has proved this not to be the case. Moreover, yield evidence suggested that the molecule wouldn’t interfere with clinical treatment for metabolic disorders.

The study began with a crop of mouse models where half of them were given a high-cholesterol, high-calorie diet alongside a daily nobiletin supplement regimen and the other half were made to follow a high-fat diet without any augmentation. The results demonstrated that those animals that received nobiletin retained their slim figures in spite of consuming a high-calorie diet. And, conversely, the mice in the second group not only gained weight quicker but also developed an excess of blood fats and higher insulin resistance.

The authors explained that, in mice models that already had all the negative symptoms of obesity, nobiletin could be used to reverse the symptoms and also to regress plaque build-up in the arteries. The results also highlighted the fact that nobiletin is not acting on AMP Kinase and is bypassing the major regulator of how the body uses fat.

The researchers aren’t sure of how the molecule is being capable of reversing obesity or how long the mechanisms activated by orange will remain. However, they are fairly confident that their findings will be translatable to some degree in human subjects.