The popular talk show host will join fellow winners legendary actor James Earl Jones and makeup artist Dick Smith at the Nov. 12 dinner in Hollywood.
Winfrey will receive the Jean Hersholt Humanitarian Award, according to the Board. Previous winners include Jerry Lewis (2009), Quincy Jones (1995) and Elizabeth Taylor, who shared the honor with Audrey Hepburn in 1993.
The 57-year-old Winfrey was nominated for her first Academy Award for Best Supporting Actress after her performance in Steven Spielberg's 1985 film, "The Color Purple."
On Jan. 1, Winfrey launched her own cable network, OWN: Oprah Winfrey Network, and later bid adieu to her 25-year-old talk show, "The Oprah Winfrey Show," on May 25.
Here's a photo tribute to Oprah Winfrey, Oscar winner.
Presenter Oprah Winfrey stands on stage during the 83rd Academy Awards in Hollywood, California, February 27, 2011.REUTERSU.S. President Barack Obama and first lady, Michelle Obama, appear with Oprah Winfrey during a taping of her television show, "The Oprah Winfrey Show," at Harpo Studios in Chicago, April 27, 2011.REUTERSOprah Winfrey gestures next to former NBA star Michael Jordan during the taping of "Oprah's Surprise Spectacular" in Chicago May 17, 2011. Winfrey kicked off one of her last-ever national talk shows on Tuesday with hugs from Tom Hanks, Tom Cruise and Madonna in a packed Chicago arena.REUTERSOprah Winfrey shares a laugh with actor Tom Cruise during the taping of "Oprah's Surprise Spectacular" in Chicago May 17, 2011. Winfrey kicked off one of her last-ever national talk shows on Tuesday with hugs from Tom Hanks, Tom Cruise and Madonna in a packed Chicago arena.REUTERSVancouver Canucks fans hold cardboard cutouts of Oprah Winfrey and Barack Obama before their team plays the Boston Bruins in Game 7 of the NHL Stanley Cup hockey playoff in Vancouver, British Columbia June 15, 2011.REUTERSOprah Winfrey (R) has her picture taken with fans Carter (L) and Wyatt (C) Lewis while attending the second day of the Allen and Company Sun Valley Conference in Sun Valley, Idaho on July 7, 2011. The annual conference that has taken place in Central Idaho since 1983 features invited attendance by world business elite, global political leaders, entertainment giants and major figures in international philanthropic and cultural spheres.REUTERSOprah Winfrey gives a thumbs-up to the media while attending the third day of the Allen and Company Sun Valley Conference in Sun Valley, Idaho July 8, 2011. The annual conference that has taken place in Central Idaho since 1983, features invited attendance by world business elite, global political leaders, entertainment giants and major figures in international philanthropic and cultural spheres.REUTERS