The popular talk show host will join fellow winners legendary actor James Earl Jones and makeup artist Dick Smith at the Nov. 12 dinner in Hollywood.
Winfrey will receive the Jean Hersholt Humanitarian Award, according to the Board. Previous winners include Jerry Lewis (2009), Quincy Jones (1995) and Elizabeth Taylor, who shared the honor with Audrey Hepburn in 1993.
The 57-year-old Winfrey was nominated for her first Academy Award for Best Supporting Actress after her performance in Steven Spielberg's 1985 film, "The Color Purple."
On Jan. 1, Winfrey launched her own cable network, OWN: Oprah Winfrey Network, and later bid adieu to her 25-year-old talk show, "The Oprah Winfrey Show," on May 25.
Here's a photo tribute to Oprah Winfrey, Oscar winner.