Microsoft sign
The Microsoft logo hangs from a window during the grand opening of Microsoft's first retail store in Scottsdale, Arizona October 22, 2009. Reuters

Vertex Pharmaceuticals, UBS AG, Barrick Gold, Microsoft Corp, Newmont Mining, Google, Align Technology, International Business Machines and Dell Inc are among the companies whose shares are moving in the pre-market trading Friday.

Gainers

Vertex Pharmaceuticals Inc. (NASDAQ:VRTX) stock rallied 52.26 percent to $80.50 in pre-market trading. The company announced Thursday that data from a Phase 2 study of VX-661 and ivacaftor showed statistically significant improvements in lung function among adults with cystic fibrosis (CF) who have two copies of the F508del mutation.

UBS AG (NYSE:UBS) stock climbed 4.81 percent to $15.92 in pre-market trading. The stock has a 52-week low of $9.78, a 52-week high of $17.66 and $56.92 billion in market capitalization.

Barrick Gold Corp. (NYSE:ABX) stock surged 3.17 percent to $18.55 in pre-market trading. The stock has a 52-week low of $17.51, a 52-week high of $43.30 and $18.00 billion in market capitalization.

Microsoft Corp. (NASDAQ:MSFT) stock gained 2.64 percent to $29.55 in pre-market trading. The company reported third quarter net profit of $6.06 billion or $0.72 per share, up from $5.11 billion or $0.60 per share in the same period last year and also topped Reuters' estimate of $0.68 per share. Quarterly revenues surged 18 percent to $20.49 billion compared to $17.41 billion in the same period a year earlier.

Newmont Mining Corp. (NYSE:NEM) stock surged 2.23 percent to $33.50 in pre-market trading. The stock has a 52-week low of $32.13, a 52-week high of $57.93 and $16.28 billion in market capitalization.

Google Inc. (NASDAQ:GOOG) stock advanced 1.82 percent to $779.85 in pre-market trading. Its first quarter net profit rose to $3.35 billion or $9.94 per share from $2.89 billion or $8.75 per share in the same quarter last year. Adjusted profit was $11.58 per share, up from $10.08 per share last year and also Reuters' estimate of a profit of $10.69 per share.

Losers

Align Technology Inc. (NASDAQ:ALGN) stock plunged 7.04 percent to $28.01 in pre-market trading. The company swung to first quarter net loss of $42.0 million or $0.52 per share compared to a net profit of $21.0 million or $0.26 per share in the same period last year. Currently, the company expects second quarter net profit to be in a range of $0.26 to $0.28 per share on revenues of $153.6 to $157.4 million, below analysts’ estimate of $0.30 per share on revenues of $158.85 million.

International Business Machines Corp. (NYSE:IBM) stock plunged 4.47 percent to $197.89 in pre-market trading. The company reported first quarter net profit of $3.03 billion or $2.70 per share, down from $3.07 billion or $2.61 per share in the same quarter last year. Quarterly revenues declined 5 percent to $23.41 billion and also fell short of Reuters' estimate of $24.69 billion.

Dell Inc. (NASDAQ:DELL) stock declined 2.94 percent to $13.54 in pre-market trading. The stock has a 52-week low of $8.69, a 52-week high of $16.61 and $24.37 billion in market capitalization.