The top pre-market NASDAQ stock market gainers are: Photronics, Transition Therapeutics, Take-Two Interactive Software, Atmel, and Mercer International. The top pre-market NASDAQ stock market losers are: Smith Micro Software, Sierra Wireless, Motricity, WSB Holdings, and Zalicus.

Gainers

Photronics Inc. (PLAB) stock jumped 14.58 percent to $7.70 in the pre-market trading, as it raised its first quarter guidance. The company increased first quarter earnings guidance to range of 17 cents to 19 cents a share from previous forecast of 10 cents to 14 cents a share. The company also raised its revenue outlook to range of $119 million to $120 million from previous range of $107 million to $111 million. Analysts predict profit of 11 cents a share on revenue of $109.09 million.

Atmel Corp. (ATML) stock advanced 6.89 percent to $15.67 in the pre-market trading, as its fourth quarter earnings exceeded Street view. Adjusted profit was $119.5 million or 25 cents a share, up from $11.3 million or 2 cents a share last year. Revenue rose 33 percent to $457.8 million. Analysts had expected profit of 16 cents a share on revenue of $436.22 million.

Shares of Transition Therapeutics Inc. (TTHI) increased 6.69 percent to $3.03 in the pre-market session.

Shares of Take-Two Interactive Software Inc. (TTWO) gained 6.53 percent to $15.49 in the pre-market session. The company narrowed its fourth quarter adjusted loss guidance to range of 45 cents to 40 cents a share from previous forecast of 60 cents to 50 cents a share, and its revenue outlook to range of $130 million to $150 million from previous range of $100 million to $150 million.

The company also raised its fiscal 2011 adjusted earnings guidance to range of 80 cents to 85 cents a share from previous range of 50 cents to 65 cents a share. The company narrowed its revenue outlook to range of $1.08 billion to $1.10 billion from previous range of $1.0 billion to $1.10 billion. The company posted third quarter adjusted profit was $49.5 million or $0.52 a share, compared to $49.2 million or $0.53 a share last year. Revenue declined 7 percent to $334.3 million.

Mercer International Inc. (MERC) stock rose 3.85 percent to $9.98 in the pre-market trading.

Losers

Smith Micro Software Inc. (SMSI) stock plunged 34.15 percent to $8.60 in the after-market trading. The company said it has suspended its 2011 revenue view, while expecting first quarter revenue of $15 million to 20 million.

Smith Micro Software said it has become aware that orders in the first quarter for core connection manager product, primarily from a key customer, will fall below expected levels. The company also anticipates that the pace of sales for mobile broadband devices using software will begin to return to more typical order levels in future quarters.

Shares of Sierra Wireless Inc. (SWIR) plummeted 25.16 percent to $11.60 in the pre-market trading, as its fourth quarter earnings and revenue came in below Street expectations. Adjusted profit was $4.9 million or 16 cents a share, up from $3.7 million or 12 cents a share last year. Revenue rose 16 percent to $167.2 million. Analysts had expected profit of 23 cents a share on revenue of $174.12 million.

Sierra Wireless expects first quarter adjusted results between loss 6 cents and breakeven per share and revenue of $140 million to $145 million, while Street predicts profit of 15 cents a share on revenue of $167.92 million. For the full year 2011, the company expects solid revenue and earnings growth driven by a strong second half.

In the first quarter of 2011, Sierra Wireless expects revenue to decline significantly from the fourth quarter of 2010. The company expects this sequential decline to be driven primarily by lower AirCard sales as operator customers prepare to transition to its new 4G products and lower embedded module sales to a single large consumer M2M customer.

Motricity, Inc. (MOTR) stock tumbled 17.17 percent to $18.24 in the pre-market trading, as it guided first quarter revenue below Street view. The company expects first quarter revenue of $32 million to $33 million, while Street predicts $42.23 million, and adjusted earnings of $0.5 million to $1 million. For fiscal 2011, Motricity projects revenue of $170 million to $180 million, while Street forecasts $173.59 million, and adjusted profit of $25 million to $30 million.

Motricity reported fourth quarter adjusted profit of $5.7 million or 14 cents a share, compared to a loss of $2.9 million or 7 cents a share last year. Revenue rose 42 percent to $36.01 million. Analysts had expected profit of 13 cents a share on revenue of $35.65 million.

WSB Holdings, Inc. (WSB) stock lost 12.09 percent to $2.98 in the pre-market trading.

Shares of Zalicus Inc. (ZLCS) declined 6.04 percent to $2.49 in the pre-market session. The company said it currently plans to hold its 2011 Annual Meeting of Stockholders on May 24, 2011 at 8:30 am ET at its offices located at 245 First Street, Third Floor, Cambridge, MA 02142. Stockholders of record as of April 7, 2011 are entitled to notice of and to vote at the 2011 Annual Meeting of Stockholders.

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