The top pre-market NASDAQ gainers are: Tudou Holdings, Ku6 Media Co, Zoll Medical Corp, Orexigen Therapeutics and Meru Networks. The top pre-market losers are: Anthera Pharmaceuticals, Human Genome Sciences, Yongye International, Logitech International and Oracle Corp.

Gainers:

Tudou Holdings Ltd. (TUDO) stock climbed 166.41 percent to $41 in pre-market trading. Youku Inc. and TUDO announced Monday that they have signed a definitive agreement for Tudou to combine with Youku in a 100 percent stock-for-stock transaction.

Ku6 Media Co., Ltd. (KUTV) stock climbed 28.57 percent to $2.70 in pre-market trading.

Zoll Medical Corp. (ZOLL) stock climbed 23.66 percent to $92.87 in pre-market trading session. Asahi Kasei Corp. and ZOLL jointly announced that Asahi Kasei Asahi has entered into an agreement to acquire all of the outstanding common stock of Zoll through a cash tender offer for approx. $2.21 billion.

Orexigen Therapeutics, Inc. (OREX) stock surged 20.27 percent to $4.45 in pre-market trading session. The company stock was upgraded to buy rating from neutral rating at Bank of America.

Meru Networks, Inc. (MERU) stock climbed 11.38 percent to $4.99 in pre-market trading session. The stock has a 52-week low of $3.16, a 52-week high of $22.19 and $78.71 million in market capitalization.

Losers:

Anthera Pharmaceuticals, Inc. (ANTH) stock slumped 53.12 percent to $3.01 in pre-market trading. The company announced Friday that the VISTA-16 Data Safety Monitoring Board (DSMB) has recommended stopping the VISTA-16 clinical study due to a lack efficacy that could not be reasonably overcome in the remainder of the trial.

Human Genome Sciences, Inc. (HGSI) stock plunged 4.01 percent to $7.90 in pre-market trading. The stock has a 52-week low of $6.51, a 52-week high of $30.15 and $1.64 billion in market capitalization.

Yongye International, Inc. (YONG) stock declined 3.6 percent to $3.48 in pre-market trading. The Company will report its fourth quarter and fiscal 2011 earnings before the U.S. market opens on March 15, 2012.

Logitech International S.A. (LOGI) stock declined 2.03 percent to $7.71 in pre-market trading.

Oracle Corp. (ORCL) stock declined 1.49 percent to $29.68 in pre-market trading session. The company stock was downgraded to hold rating from buy rating at Jefferies.

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