San Francisco's mayor on Friday declared a state of emergency in a downtown district reeling from a severe spike in fatal drug overdoses driven mainly by fentanyl.

The Tenderloin neighborhood, just south of tourist and shopping hotspot Union Square, has emerged as the city's epicenter of an opioid crisis that has surged across the nation.

"We are losing over two people a day to drug overdoses, mostly to fentanyl, and mostly in the Tenderloin and SoMa," said city supervisor Matt Haney, referring to a neighboring central district.

"This is a public health emergency demanding a crisis level response, with massive urgency, coordination, and determination to confront this epidemic."

Drug overdoses in San Francisco have risen sharply since the mid-2010s as highly potent synthetic opioid fentanyl infiltrated the city.

US drug overdose deaths surged to more than 100,000 this year for the first time during the Covid-19 pandemic, exacerbated by a flood of fake online pills
US drug overdose deaths surged to more than 100,000 this year for the first time during the Covid-19 pandemic, exacerbated by a flood of fake online pills AFP / Patrick T. FALLON

A record 711 died from overdoses last year, with 2021 deaths projected to fall slightly below that, according to a San Francisco Chronicle tracker.

The declaration signed by Mayor London Breed on Friday allows officials to quickly open shelters and mental health services by bypassing zoning, planning and contract procurement rules.

It emulates Breed's early move to declare a citywide Covid-19 emergency in February 2020.

US drug overdose deaths surged to more than 100,000 this year for the first time during the Covid-19 pandemic, exacerbated by a flood of fake online pills.

The Tenderloin district near City Hall has long been a hub for homelessness, drug use and drug dealing, and Breed said the measure would "disrupt the illegal activity in the neighborhood" and "get people the treatment and support they need."

Substance abuse issues have soared amid the pandemic, as many treatment programs have stopped or been rolled back, and alcohol and drug consumption rates have risen.