Robin van Persie scored twice to give Manchester United a 2-1 at Southampton and take them into third place in the Premier League.
Liverpool and Basel will battle for a place in the last 16 of the Champions League on Tuesday.
Arsenal will attempt to rebound from their weekend loss when they visit Galatasaray in their final match of the Champions League group stage.
Manchester United manager Louis van Gaal has said that striker Radamel Falcao is not fit enough to start against Southampton.
Down for most of the first half, Barcelona scored five goals in 45 minutes to silence Espanyol.
Cristiano Ronaldo has 24 La Liga goals this term, but his 22nd may come under scrutiny.
Arsenal suffered a 3-2 defeat to Stoke City at the Britannia Stadium.
Two goals from Papiss Cissé gave Newcastle United a 2-1 victory over previously unbeaten Chelsea at St James’ Park.
José Mourinho claims to have no interest in the records Chelsea could secure by avoiding defeat at Newcastle United on Saturday.
The final draw for the 2015 FIFA Women’s World Cup will take place in Canada’s capital Ottawa on Saturday.
The LA Galaxy host the New England Revolution in MLS Cup final on Sunday in what will be Landon Donovan’s final match.
Arsenal have further injury concerns ahead of Saturday’s match at Stoke City.
Liverpool’s scoring problems this season mean they are thought to be seeking a forward in the January transfer window.
Arsenal face a tough task to continue their recent winning run when visiting Stoke City’s Britannia Stadium on Saturday.
Manchester United could face a battle to land their leading transfer targets in January.
Alexis Sánchez scored a late winner to give Arsenal a 1-0 victory over Southampton at the Emirates Stadium.
Chelsea beat Tottenham 3-0 to maintain their 24-year undefeated run against their London rivals at Stamford Bridge.
Arsenal could have their work cut out to sign a defender in the January transfer window.
Barcelona will visit lowly Huesca in the first leg of their Copa del Rey last-32 tie on Wednesday.
Steven Gerrard was on target to help Liverpool beat Leicester City 3-1 at the King Power Stadium
Manchester United won their fourth game in a row, with a 2-1 victory over Stoke City at Old Trafford.
Real Madrid beat Cornellà 9-1 on aggregate to secure their place in the last 16 of the Copa del Rey.
Arsenal could face another injury crisis when they take on Southampton on Wednesday.
Chelsea will aim to bounce back from a disappointing draw with Sunderland when hosting London rivals Tottenham on Wednesday.
Real Madrid will field a much-changed lineup for their Copa del Rey last-32 second leg against Cornellà.
Manchester United continue be linked with transfers to bolster their ailing defense in January.
Brendan Rodgers hopes his Liverpool side have turned a corner ahead of their trip to take on Leicester City on Tuesday.
January is again set to be a hectic transfer window for Arsenal and manager Arsène Wenger.
Cristiano Ronaldo, Lionel Messi and Manuel Neuer all have strong cases to win the 2014 FIFA Ballon d’Or.
Manchester United boss Louis van Gaal has voiced his concerns about the hectic festive fixture list as he prepares for Tuesday’s visit of Stoke City.