The Pittsburgh Steelers visit the Cleveland Browns to kick off Week 3 of the 2022 NFL season. The "Thursday Night Football" matchup could have major implications for the AFC North race with all four teams in the division coming off losses.

The game between the Steelers and Browns starts at 8:15 p.m. ET. Fans across the country can watch the contest on Prime Video. "Thursday Night Football" in Week 3 will be broadcast locally in Pittsburgh by WPIX Channel 11 and WEWS News 5 in Cleveland.

Prime Video costs $8.99 per month for a standalone subscription. An Amazon Prime membership also includes access to Prime Video, and it costs either $14.99 per month or $139 per year.

The season's first Thursday night game on Prime Video was a divisional battle that came down to the wire. The Kansas City Chiefs defeated the Los Angeles Chargers 27-24 in Week 2. The Chiefs came back from a 17-7 deficit, capped off by Jaylen Watson's 99-yard interception return for a touchdown.

Cleveland opened as a 3.5-point favorite, but the odds have moved even more in the Browns' direction. The point spread is up to five points at DraftKings Sportsbook.

The Browns would be 2-0 if they didn't become the first team in two decades to blow a 13-point lead with less than two minutes remaining in regulation. Cleveland was upset at home by the New York Jets 31-30 in Week 2.

The Steelers were never close to defeating the New England Patriots in their 17-14 loss. Mitchell Trubisky has failed to throw for more than 194 yards, one touchdown or a 78.2 passer rating in either of his starts with Pittsburgh.

The contest could be decided by big plays on defense. Pittsburgh was able to upset the Cincinnati Bengals in the season opener behind five turnovers.

Jacoby Brissett has thrown for 376 yards, two touchdowns and one interception as Cleveland's starter. It's been Nick Chubb's 228 yards on 5.8 yards per carry that have carried the Browns' offense.

Pittsburgh went 2-0 against Cleveland a season ago. The Browns were held to 24 total points in the two games, and Chubb only racked up 119 yards on the ground.

The Steelers have the better head coach, potentially giving them an even greater advantage on a short week. The Browns are 26th in scoring defense in the early going. Pittsburgh ranks 12th in the league in points per game allowed.

If the Steelers can successfully contain Chubb, once again, they can steal a key divisional matchup on the road.

Prediction: Pittsburgh over Cleveland, 20-17

Mitch Trubisky, Pittsburgh Steeler
Mitch Trubisky #10 of the Pittsburgh Steelers warms up before a preseason game against the Seattle Seahawks at Acrisure Stadium on August 13, 2022 in Pittsburgh, Pennsylvania. Justin Berl/Getty Images