The Red Devils host Basel at Old Trafford.
The Gunners have several injuries going into their match at Emirates.
Manchester United will face FC Basel at Old Trafford in their second Group C encounter in the UEFA Champions League.
Two teams with an illustrious history in the competition will face-off at the Santiago Bernabeu as Real Madrid host Ajax Amsterdam in their UEFA Champions League group D encounter.
Manchester United will face FC Basel at Old Trafford in their second Group C encounter in the UEFA Champions League.
Manchester United will play FC Basle in their second UEFA Champions League group game on Tuesday, but they face the prospect of playing without eight first-team contenders.
Here are the top 10 players who could make a difference this season.
It'll be an interesting night of European football as the continents two champions from last season - Barcelona and FC Porto - take on each other in the UEFA Super Cup.
Arsenal will travel to Udine, Italy to face Udinese in the second-leg of the Champions League Qualifier at the Stadio Friuli on Wednesday.
Arsenal will travel to Udine, Italy to face Udinese in the second-leg of the Champions League Qualifier at the Stadio Friuli on Wednesday.
Although Arsenal began their post-Fabregas era with a win, it was a far from convincing performance in the 1-0 win in the first leg of Champions League qualifying tie.
Having lost their captain Cesc Fabregas, who stood for everything good about the club, Arsenal will attempt to bounce back and secure a place in the group stages of the UEFA Champions League as they take on Udinese in the first of a two-legged encounter at the Emirates.
Arsenal are close to selling Samir Nasri to Manchester City, but have risked naming both Nasri and Cesc Fabregas in their Champions League squad for the qualifier against Udinese.
The United legend opened the scoring for the Red Devils just after eight minutes with a trademark right footed drive.
Arsenal have been handed a tough route into the UEFA Champions League group stages after they drew Italian side Udinese in the qualifying play-offs.
Both Fabianski and Szczesny have established themselves in the club.
Lionel Messi, Cristiano Ronaldo and Xavi Hernandez have been shortlisted for the new UEFA Best Player in Europe Award.
Thierry Henry, who spent eight years with the Gunners while scoring 174 goals in 254 appearances, is set to face his old side again when New York Red Bulls take on Arsenal in the pre-season Emirates Cup.
Spanish giants Real Madrid have appealed with Uefa against the imposition of a five-match European ban on their manager Jose Mourinho after the comments he made post the Champions League semifinal first leg against Barcelona.
Manchester United's top scorer Dimitar Berbatov looks likely to leave the club after being excluded from the Champions League final squad against Barcelona on Saturday.
In what panned out to be an entertaining Champions League final, Barcelona capped a commanding performance to win 3-1 against Manchester United at the Wembley Stadium.
The spirit-filled final match of UEFA Champions League was over with Barcelona taking the trophy home and Manchester United was not able to revenge their defeat from two years ago , when they also lost by two points against Barcelona in the 2009's Champion's League final.