The top after-market Nasdaq gainers Friday were The Medicines Company, Ixia, Oplink Communications Inc, CEVA and ADTRAN Inc.

The top after-market Nasdaq losers were Leap Wireless International, Sangamo BioSciences Inc, Affymax Inc, Oclaro and Diodes Incorporated.

Gainers

The Medicines Company (MDCO) shares climbed 3.54 percent to $4.75 in post-market trading. The company shares lost 5.74 percent in regular trading Friday after it announced it voluntarily discontinued its Phase 2b dose-ranging study of MDCO-2010, a serine protease inhibitor which was being developed to reduce blood loss during surgery.

Ixia (XXIA) shares surged 3.19 percent to $17.17 in post-market trading. The company shares have a 52-week trading range of $8.19- 17.40 and a market capitalization of 1.21 billion.

Oplink Communications (OPLK) shares advanced 3.23 percent to $15.68 in post-market trading. The company stock lost 3 percent in regular trading Friday.

CEVA (CEVA) shares rose 3.16 percent to $13.73 in post-market trading. The company shares have a 52-week trading range of $13.25-$34.50 and a market capitalization of 300.63 million.

ADTRAN Inc (ADTN) shares gained 2.96 percent to $16.67 in post-market trading. The company stock lost 2.88 percent in regular trading Friday.

Losers

Leap Wireless International (LEAP) shares plunged 5.02 percent to $5.87 in post-market trading. The company shares gained 5.64 percent in regular trading.

Sangamo BioSciences Inc (SGMO) shares declined 3.78 percent to $6.11 in post-market trading. The company shares gained 3.93 percent in regular trading.

Affymax Inc (AFFY) shares plunged 3.60 percent to $21.95 in post-market trading.

Oclaro Inc (OCLR) shares declined 3.42 percent to $2.54 in post-market trading. The company shares declined after it had announced that for the first quarter of 2013, it expected preliminary revenues of approximately $149 million, compared to the low end of its guidance of $154 million, previously issued July 31, 2012. According to analysts’ estimates the company was expected to report revenue of $162 million for the first quarter.

Diodes Inc (DIOD) shares fell 3.04 percent to $16.61 in post-market trading. The company shares gained over 3 percent in regular trading.