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The top after-market NASDAQ gainers Wednesday were MediciNova, Unilife Corp, Accuray Inc, Idenix Pharmaceuticals and Anika Therapeutics Inc. The top after-market NASDAQ losers were Groupon, BroadSoft, Inc, Gulfport Energy Corp, ABIOMED and Orexigen Therapeutics Inc.

Gainers

MediciNova, Inc. (NASDAQ:MNOV) shares rallied 20.25 percent to $3.80 in post-market trading. The stock climbed more than 40 percent in the last two days after the company said that it had received Fast Track designation from the U.S. Food and Drug Administration for MN-166 (ibudilast) for the treatment of methamphetamine dependence.

Unilife Corp. (NASDAQ:UNIS) shares surged 3.91 percent to $2.66 in post-market trading. The stock has a 52-week low of $2.01, a 52-week high of $5.17 and $218.57 million in market capitalization.

Accuray Inc. (NASDAQ:ARAY) shares gained 3.85 percent to $4.44 in post-market trading. The stock plunged more than 3.5 percent in regular trading.

Idenix Pharmaceuticals, Inc. (NASDAQ:IDIX) shares rose 3.53 percent to $4.27 in post-market trading. The stock has a 52-week low of $3.35, a 52-week high of $12.60 and $551.60 million in market capitalization.

Anika Therapeutics Inc. (NASDAQ:ANIK) shares advanced 3.27 percent to $11.06 in post-market trading. Its fourth quarter net profit rose to $4.5 million or $0.31 per share from $2.9 million or $0.21 per share in the same period last year.

Losers

Groupon, Inc. (NASDAQ:GRPN) shares tumbled 25.95 percent to $4.43 in post-market trading. Its fourth quarter net loss widened to $81.1 million from $65.4 million in the same period a year-earlier. Revenue rose 30 percent to $638.3 million compared to $492.2 million last year. Groupon currently expects the first quarter revenue to be in a range of $560 to $610 million, below the analysts’ estimate of $650.29 million.

BroadSoft, Inc. (NASDAQ:BSFT) shares slumped 24.46 percent to $23.35 in post-market trading. Its fourth quarter adjusted net profit rose to $0.47 per share from $0.38 per share in the same period last year. The company currently expects the first quarter adjusted net profit to be in a range of $0.02 to $0.12 per share on revenues of $37 to $40 million, below the analysts’ estimate of a net profit of $0.34 per share on revenues of $43.62 million.

Gulfport Energy Corp. (NASDAQ:GPOR) shares slumped 8.47 percent to $36.00 in post-market trading. The company stock climbed more than 9 percent in regular trading.

ABIOMED, Inc. (NASDAQ:ABMD) shares plunged 7.99 percent to $15.05 in post-market trading. The stock has a 52-week low of $11.80, a 52-week high of $26.17 and $630.81 million in market capitalization.

Orexigen Therapeutics Inc. (NASDAQ:OREX) shares declined 6.91 percent to $5.05 in post-market trading. The company’s stock climbed more than 7 percent in regular trading.

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