The top after-market Nasdaq gainers Wednesday were Pegasystems Inc, Tessera Technologies Inc, Responsys Inc, HomeAway Inc and Avis Budget Group Inc, while the top after-market Nasdaq losers were United Therapeutics Corporation, Rubicon Technology Inc, Achillion Pharmaceuticals and Tesla Motors Inc.

Gainers

Pegasystems Inc (NASDAQ:PEGA) shares surged 20.41 percent to $30.50 in post-market trading. The company reported $0.65 earnings per share for the fourth quarter, topping the analysts’ estimate of $0.33. The company revenues stood at $143.80 million for the fourth quarter, compared to the consensus estimate of $122.58 million.

Tessera Technologies Inc (NASDAQ:TSRA) shares climbed 11.37 percent to $19.00 in post-market trading Wednesday. The company stock has a 52-week average of $12.77-$19.93 and a market capitalization of $891.18 million.

Responsys Inc (NASDAQ:MKTG) shares advanced 9.03 percent to $7.00 in post-market trading. The company reported a fourth quarter EPS of $0.07, $0.02 better than the analysts' estimate of $0.05. Revenue for the quarter came in at $44.7 million versus the consensus estimate of $42.47 million.

HomeAway Inc (NASDAQ:AWAY) shares gained 8.89 percent to $51.27 in post-market trading. The company announced that for first quarter of 2013, it expects total revenues to be in the range of $78.0 to $79.0 million and adjusted EBITDA to be in the range of $19.0 to $20.0 million. For fiscal 2013, it expects total revenue to be in the range of $339.0 to $343.0 million and adjusted EBITDA to be in the range of $97.5 to $100.5 million. Analysts were expecting the company to report revenues of $78 million and EBITDA of $19 million for first quarter of 2013; and revenue of $337 million and EBITDA of $101 million for fiscal 2013.

Avis Budget Group Inc (NASDAQ:CAR) shares advanced 6.10 percent to $24.53 in post-market trading. The company stock has a 52-week average of $11.93-$24.90 and a market capitalization of $2.46 billion.

Losers

United Therapeutics Corporation (NASDAQ:UTHR) shares declined 8.17 percent to $10.00 in post-market trading. The company stock has a 52-week average of $40.34-$59.00 and a market capitalization of $2.86 billion.

Rubicon Technology Inc (NASDAQ:RBCN) shares dropped 8.15 percent to $5.30 in post-market trading. The company share has a 52-week average of $5.31-$12.88 and a market capitalization of $130.04 million.

Achillion Pharmaceuticals (NASDAQ:ACHN) shares slumped 7.35 percent to $8.83 in post-market trading. The company stock has a 52-week average of $5.42-$11.36 and a market capitalization of $757.80 million.

Tesla Motors, Inc (NASDAQ:TSLA) shares fell 6.07 percent to $36.20 in post-market trading. The company stock has a 52-week average of $25.52-$40.00 and a market capitalization of $4.39 billion.