Nasdaq
Commuters pass by the NASDAQ Market site in New York, May 21, 2012. REUTERS

The top after-market Nasdaq gainers Tuesday were Wendy's Company, Santarus Inc, Sarepta Therapeutics Inc, Glu Mobile Inc and Facebook.

The top after-market Nasdaq losers were FEI Company, Education Management Corporation, ONYX Pharmaceuticals Inc, Bloomin' Brands Inc and Francesca's Holdings Corporation.

Gainers

Wendy's Company (WEN) shares climbed 4.63 percent to $ 4.52 in after-hours trading Tuesday. Zacks reiterated the neutral rating on the shares of Wendy's in a research report sent to the investors Tuesday morning.

The shares of Santarus Inc (SNTS) rose 3.47 percent in post-market to close at $7.30. The company won a U.S. appeals court ruling that lets it pursue efforts to block Par Pharmaceuticals Cos from selling generic versions of the heartburn medicine Zegerid until 2016, the Bloomberg reported.

Sarepta Therapeutics Inc (SRPT) shares advanced 2.68 percent to $15.32 in post-market trading. The company announced that it had secured a new contract for approximately $3.9 million to evaluate the feasibility of an intramuscular route of administration using AVI-7288, the company's candidate for treatment of Marburg virus.

Glu Mobile Inc (GLUU) shares gained 2.46 percent and reached $5.00 in after-hours trading. The company shares have a 52-week trading range of $1.80-$5.90 and 317.96 million in market capitalization.

Facebook (FB) shares surged 1.98 percent to $18.08 in after-hours trading. The company shares slipped 1.82 percent to $17.73 in the regular trading and were near to its 52-week low of $17.55.

Losers

FEI Company (FEIC) shares slumped 35.80 percent to $35.65 in post-market trading Tuesday. The company had gained 3.39 percent in regular trade.

Education Management Corporation (EDMC) shares plunged 6.12 percent to $ 2.99 in post-market trading. The company shares declined after the Harwood Feffer LLP said it was investigating the potential claims against the board of directors of Education Management Corp. concerning whether the board had breached its fiduciary duties to shareholders.

ONYX Pharmaceuticals, Inc (ONXX) shares lost 5.06 percent in after-hours trading to reach $72.03. The company shares had gained 5.49 percent in regular trading.

Bloomin' Brands, Inc (BLMN) shares dropped 4.76 percent to $ 12.81 in after-hours trading. The company announced the second quarter results and said that for fiscal 2012, it expected comparable restaurant sales growth of at least 3 percent and total revenues of approximately $4 billion.

Francesca's Holdings Corporation (FRAN) shares dropped 3.77 percent to $34.71 in after-market trading. Company's chief executive John De Meritt, who helped the women's specialty retailer better understand fast-changing fashion trends, will retire at the end of this year.