The top pre-market NASDAQ stock market losers are: Inspire Pharmaceuticals, DryShips, Capitol Federal Financial, Netflix, Intel, Amkor Technology, IMAX, GSI Commerce, and Ctrip.com International.

Inspire Pharmaceuticals, Inc. (ISPH) lost 58.93 percent to $3.45 in the pre-market session, heading below the 52-week low of $4.42. The company said its second Phase 3 clinical trial, TIGER-2, for denufosol tetrasodium to treat cystic fibrosis did not achieve statistical significance for its primary efficacy endpoint, which was change from baseline in FEV1 at the Week 48 Endpoint.

Cystic fibrosis is an inherited chronic disease that affects the lungs and digestive systems of about 70,000 people worldwide, according to the Cystic Fibrosis Foundation. A defective gene and the protein it produces cause the body to produce thick, sticky mucus that clogs the lungs, leads to lung infections and obstructs the pancreas.

DryShips, Inc. (DRYS) plummeted 2.19 percent to $5.37 in the pre-market trading.

Capitol Federal Financial (CFFND) fell 0.92 percent to $11.80 in the pre-market trading.

Netflix, Inc. (NFLX) declined 0.47 percent to $174.87 in the pre-market trading.

Intel Corp. (INTC) decreased 0.38 percent to $20.95 in the pre-market session.

Amkor Technology, Inc. (AMKR) slid 0.27 percent to $7.39 in the pre-market session.

IMAX Corp. (IMAX) declined 0.25 percent to $28 in the pre-market trading.

GSI Commerce Inc. (GSIC) moved down 0.13 percent to $23.20 in the pre-market trading.

Ctrip.com International Ltd. (CTRP) decreased 0.12 percent to $40.40 in the pre-market session.

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