Hurricane Matthew is expected to make landfall late Thursday night.
Evacuations were ordered in Florida, Georgia and South Carolina after the massive storm pummeled Haiti and Cuba earlier this week, killing 25 people.
Four deaths have been documented in the Dominican Republic and five were reported in Haiti.
Thousands of flights have been cancelled, and over 100,000 homes are without power in Florida as the hurricane made landfall with 115 mph wind gusts.