Buffalo's EJ Manual will start ahead of the injured Kevin Kolb in Sunday's preseason game at Lucas Oil Stadium.
Two teams that missed the postseason last year, hope to climb back into contention with new players on the defensive line and in the backfield.
The Dallas Cowboys will visit the Oakland Raiders in their second preseason game of 2013.
The Chicago Bears will visit the Carolina Panthers in their first preseason game of 2013.
Top rushing rookie Eddie Lacy will sit out for Green Bay, giving more time for fellow rookie running back Jonathan Franklin to shine at Lambeau.
Andy Reid was fired by Philadelphia after 10 seasons, and Sean Payton is returning to the sidelines after a year removed from the Bounty Gate scandal.
The Texans will rest has many as 20 players, while Minnesota hopes to vet out its plethora of receivers.
The New England Patriots will play the Philadelphia Eagles in their first preseason game of 2013.
Miami is hoping to build off its 7-9 record of a year ago, while the Jaguars continue to struggle at the bottom of the AFC.
The New York Jets will face the Detroit Lions in each team’s first preseason game of 2013.
Both teams have seen injuries take down their best receiving threats as they prep for the upcoming NFL season.
The San Francisco 49ers will face the Denver Broncos on Thursday night in a possible 2014 Super Bowl preview.
The Redskins have ruled Robert Griffin III out for the entire preseason, but that has opened up a window of opportunity for second-year quarterback Kirk Cousins to solidify his spot on the roster.
The Cincinnati Bengals will play the Atlanta Falcons in their first preseason game of 2013.
The Baltimore Ravens will visit the Tampa Bay Buccaneers in Week 1 of the 2013 NFL preseason.
Cleveland and St. Louis get to showcase some of their rookies in the first preseason action for both clubs.
DirectTV released a hilarious music video featuring the Manning brothers. Take a look at some of the best moments in GIFs
Several players will be looking to solidify starting roles when the Dallas Cowboys play the Oakland Raiders in the preseason.
A new report claims that ESPN "Numbers Never Lie" co-hosts Hugh Douglas and Michael Smith got into a heated argument after Douglas allegedly called Smith an "Uncle Tom" at an Orlando party.
The Manning brothers shine and delight in this rap video advertisement for DirecTV.
In response to this unfortunate incident, the Eagles, the NFL, and even Cooper himself expressed their "horror" over his statement.
Hugh Douglas and Michael Smith, co-hosts of ESPN's "Numbers Never Lie" TV show, allegedly had to be separated following a heated altercation at a party in Orlando, Fla.