Ireland and the Netherlands on Sunday became the latest countries to suspend their rollouts of AstraZeneca jabs over concerns about post-jab blood clots despite the firm insisting there was no risk, as most Italians were bracing for a new round of restrictions.

Vaccinations are a key tool to end the worst of a pandemic that has killed more than 2.6 million people since it emerged in China in late 2019.

Italy is to introduce new restrictions from Monday until April 6
Italy is to introduce new restrictions from Monday until April 6 AFP / Marco Bertorello

So far more than 350 million doses have been doled out across the world, but countries including Denmark, Norway and Bulgaria suspended the rollout of jabs from the Anglo/Swedish pharma giant this week after reports of blood clots developing in patients who had received the shot.

The World Health Organization, Europe's medicines watchdog, governments and experts have stressed that no causal link has been established between the vaccine and blood clotting and insisted that the shot is safe.

Supporters of the "Men in Black Denmark" movement demonstrate against restrictions implemented to fight the spread of the novel coronavirus on two people were arrested on the sidelines of a weekend protest against anti-coronavirus restrictions in Copenhag
Supporters of the "Men in Black Denmark" movement demonstrate against restrictions implemented to fight the spread of the novel coronavirus on two people were arrested on the sidelines of a weekend protest against anti-coronavirus restrictions in Copenhagen. Ritzau Scanpix / Martin Sylvest

An AstraZeneca spokesman said it had found no evidence of increased risk of blood clot conditions after analysing reported cases from more than 17 million doses.

"In fact, the reported numbers of these types of events for COVID-19 Vaccine AstraZeneca are lower than the number that would have occurred naturally in the unvaccinated population," said the spokesman.

A 6 pm curfew remains in place across France and restaurants, cafes, cinemas, theatres and large shopping centres have been shut
A 6 pm curfew remains in place across France and restaurants, cafes, cinemas, theatres and large shopping centres have been shut AFP / Valery HACHE

AstraZeneca's shot is among the cheapest available and forms a bulk of deliveries to poorer nations under the WHO-backed Covax initiative, which aims to ensure vaccines get to all parts of the globe.

IMAGESItalians eat at restaurants and walk the streets of Trastevere in Rome on the eve of a partial lockdown. Schools, restaurants, shops and museums will close across most of the country, a year after it became the first European country to face a major
IMAGESItalians eat at restaurants and walk the streets of Trastevere in Rome on the eve of a partial lockdown. Schools, restaurants, shops and museums will close across most of the country, a year after it became the first European country to face a major outbreak. AFPTV / Giovanni GREZZI

A spokesman for Ireland's health ministry told AFP that the rollout had been "temporarily deferred" after the country's advisory panel recommended a suspension because of concerns raised by Norwegian officials.

AstraZeneca's shot is among the cheapest available
AstraZeneca's shot is among the cheapest available AFP / MIGUEL RIOPA

The Dutch health ministry similarly said it was suspending the rollout as a precaution.

Norwegian officials said on Saturday the country had reports of people "bleeding under the skin" and "severe cases of blood clots or brain haemorrhages in younger people" who had received the shot.

Graphic showing the change in the number of hospital and intensive care unit admissions in France, as of March 13.
Graphic showing the change in the number of hospital and intensive care unit admissions in France, as of March 13. AFP / Sophie RAMIS

AstraZeneca became embroiled in a bitter row with European leaders earlier in the year when it announced it would not be able to supply the number of doses it had promised.

Since then, European leaders have bitterly criticised the company and cast doubt on the vaccine's efficacy while at the same time blocking some exports of doses to destinations outside the European Union.

French Prime Minister Jean Castex, however, defended his country's decision to carry on with the AstraZeneca jab saying on Sunday France had found no reason to suspend the rollout.

"At this stage, we must have confidence in this vaccine," he said, highlighting instead the danger of leaving large sections of the population unprotected from Covid.

France is facing a hospital crisis with intensive care beds in the Paris region running out and patients having to be taken to other parts of the country.

While France is hoping to avoid being plunged back into a national lockdown, neighbouring Italy is set to reimpose restrictions across most of the nation on Monday -- a year after it became the first European nation to face a major outbreak.

Schools, restaurants, shops and museums will close with Health Minister Roberto Speranza saying he hoped the measures and vaccination programme would allow restrictions to be relaxed in the second half of spring.

"Each dose of vaccine injected is a step in the direction of the way out of the crisis," he said on Sunday.

Across the world, businesses and families are still counting the cost of the lockdowns and other measures that have left millions without jobs -- and forced others to carry on working even if they feel they are lacking protection.

"It went from 'get these drinks and orders done as fast as possible' to 'do all of that, and try not to bring a deadly virus home to your vulnerable family,'" the 21-year-old told AFP.

Coronavirus