The NFL Week 13 schedule might feature the best slate thus far in the 2022 season. Six contests include a pair of teams with have winning records, and nine games have spreads of four points or less.

Here are picks against the spread for every game in Week 13 and updated betting odds from FanDuel and DraftKings Sportsbook.

Buffalo Bills (-4.5) at New England Patriots

After the Patriots beat the Bills in poor weather conditions for their first matchup of 2021, Buffalo dominated New England in their final two meetings. Josh Allen threw for 622 yards, eight touchdowns and no interceptions as the Bills won by a combined score of 80-38. Don't be surprised if Thursday's game has a similar outcome.

Prediction ATS: Buffalo

New York Jets (+3) at Minnesota Vikings

Let's see how Mike White plays on the road against a playoff team. The Jets quarterback had eight interceptions in 132 attempts last season. The Vikings are undefeated against teams that have seven or fewer wins.

Predictions ATS: Minnesota

Denver Broncos (+8.5) at Baltimore Ravens

As bad as Denver's offense has been, its defense can keep this a one-score game. The Broncos have a top-three defense. Baltimore has failed to score 28 points in eight straight games, and seven of those contests were decided by fewer than six points.

Prediction ATS: Denver

Pittsburgh Steelers (-1) at Atlanta Falcons

Wins against the Saints and Colts don't all of a sudden mean that Kenny Pickett and the Steelers are going to compete for a playoff spot. Pittsburgh is 0-4 when Pickett starts and finishes a game against an opponent that has more than four wins. The Falcons are 4-2 at home.

Prediction ATS: Atlanta

Jacksonville Jaguars (-1.5) at Detroit Lions

A last-second field goal on Thanksgiving Day kept the Lions from winning their fourth straight game. Detroit is 3-0 against sub-.500 teams. The Jaguars are 1-4 on the road, giving up at least 27 points in all of those losses.

Prediction ATS: Detroit

Tennessee Titans (+5.5) at Philadelphia Eagles

The Titans should be competitive in Philadelphia. Only Buffalo has defeated Tennessee by more than four points. The Eagles have given up at least 32 points in two of their last three games. Chauncey Gardner-Johnson, the league-leader in interceptions, seems likely to sit with a rib injury.

Prediction ATS: Tennessee

Cleveland Browns (-7) at Houston Texans

Houston might not be very interested in winning games right now as it heads for the No. 1 overall pick in the draft. No one knows how former Texan Deshaun Watson will look in his Browns debut, but it probably won't matter. Eight of Houston's nine losses have come by at least seven points.

Prediction ATS: Cleveland

Washington Commanders (-1.5) at New York Giants

The Giants might just be too banged-up to beat a playoff team right now. New York is without three of its best players in the secondary and several key offensive players. Washington has a top-10 rushing defense and has won six of its last seven games.

Prediction ATS: Washington

Green Bay Packers (-3) at Chicago Bears

The Bears would be wise to rest Justin Fields while he deals with a shoulder injury. Darnell Mooney is done for the season. Aaron Rodgers wants to play in Week 13 and has a career 23-5 record against Chicago.

Prediction ATS: Green Bay

Miami Dolphins (+4) at San Francisco 49ers

The Dolphins are the AFC's version of the 49ers. Miami's offense has arguably the best group of playmakers in the conference, led by a coach who came from San Francisco's offense. Tua Tagovailoa has played much better than Jimmy Garoppolo this season, and that could be the difference Sunday in an upset.

Prediction ATS: Miami

Seattle Seahawks (-8) at Los Angeles Rams

This point spread has probably gotten too high. Despite all their injuries, the Rams only trailed the Chiefs by 10 points in Kansas City halfway through the fourth quarter. Whoever is at quarterback for the Rams could find success against Seattle's 29th ranked defense.

Prediction ATS: Los Angeles

Los Angeles Chargers (-2) at Las Vegas Raiders

A victory might put Los Angeles in playoff positioning, but the Chargers seem to always come up short just when it looks like they're turning a corner. The Raiders are up to fifth in yards per play, putting them 17 spots ahead of the Chargers. Los Angeles gives up the most yards per carry. Josh Jacobs is the league's leading rusher and can help Las Vegas pull off the upset.

Prediction ATS: Las Vegas

Kansas City Chiefs (-2.5) at Cincinnati Bengals

It's hard to forget about the AFC Championship Game, during which the Bengals figured out a way to contain Patrick Mahomes. Joe Burrow has arguably been the AFC's second-best quarterback, throwing for 21 touchdowns and four interceptions in the last 10 games. Ja'Marr Chase is expected to return from his hip injury.

Prediction ATS: Cincinnati

Indianapolis Colts (+10.5) at Dallas Cowboys

The Cowboys' vaunted pass rush could make life miserable for Matt Ryan. Indianapolis has been competitive in all three games under Jeff Saturday. Maybe the Colts can catch Dallas by surprise and keep the game close with their No. 6 ranked defense

Prediction ATS: Indianapolis

New Orleans Saints (+3.5) at Tampa Bay Buccaneers

After being shut out in Week 12, New Orleans has failed to score 13 points in three of the last four games. The Saints have lost five straight games away from home. The Bucs are seventh in scoring defense and opponents' yards per play. New Orleans has scored 19 total points in its last two meetings with Tampa Bay.

Prediction ATS: Tampa Bay

Season Record: 86-90-4

Derek Carr Davante Raiders
Derek Carr #4 and wide receiver Davante Adams #17 of the Las Vegas Raiders stand on a sideline during a preseason game against the Minnesota Vikings at Allegiant Stadium on August 14, 2022 in Las Vegas, Nevada. Ethan Miller/Getty Images