Tottenham Hotspur sacked manager Mauricio Pochettino on Tuesday following a miserable start to the campaign that has seen last season's Champions League finalists slide down the Premier League table.

Tottenham sit 14th in England's top flight after picking up just three wins from their opening 12 games, and were eliminated from the League Cup in September by fourth-tier Colchester United.

"The club can today announce that Mauricio Pochettino and his coaching staff Jesus Perez, Miguel D'Agostino and Antoni Jimenez have been relieved of their duties," Tottenham said in a statement.

Pochettino, 47, joined Spurs from Southampton in 2014 and transformed the club's fortunes despite failing to win a trophy in his five-and-a-half years in charge.

Mauricio Pochettino was sacked by Tottenham after five-and-a-half years in charge on Tuesday
Mauricio Pochettino was sacked by Tottenham after five-and-a-half years in charge on Tuesday AFP / Glyn KIRK

His side have become Champions League regulars over the past four seasons, culminating in a dramatic run to the club's first ever European Cup final in June, which they lost 2-0 to Liverpool in Madrid.

However, domestically results have been on the decline since February.

Only the faltering form of Arsenal and Manchester United allowed Spurs to cling onto a top-four finish last season as they won just three of their final 12 league games.

That form has continued at the start of this season with Pochettino leaving the club already 11 points outside the Premier League top four and 20 behind leaders Liverpool.

"We were extremely reluctant to make this change and it is not a decision the board has taken lightly, nor in haste," said Tottenham chairman Daniel Levy.

Happier times: Mauricio Pochettino celebrates reaching last season's Champions League final with Tottenham captain Hugo Lloris
Happier times: Mauricio Pochettino celebrates reaching last season's Champions League final with Tottenham captain Hugo Lloris AFP / Adrian DENNIS

"Regrettably domestic results at the end of last season and beginning of this season have been extremely disappointing.

"It falls to the board to make the difficult decisions -- this one made more so given the many memorable moments we have had with Mauricio and his coaching staff -- but we do so in the club's best interests."

The job done by Pochettino was all the more remarkable given the tight budget he was afforded by Levy for transfers and wages in comparison to Tottenham's Premier League rivals, as the club built a new stadium at a cost of over ?1 billion (1.17 billion euros).

Spurs were forced to play at temporary home Wembley for the entirety of the 2017/18 campaign and most of last season before moving into their new 62,000 capacity ground in April.

After 18 months without signing a single player, Levy finally loosened the purse strings to buy Tanguy Ndombele for a club record ?63 million ($79 million) in July and added Giovani lo Celso on loan and Ryan Sessegnon in the summer transfer window.

However, injuries have prevented that trio making an instant impact, while Pochettino bemoaned the disruptive effect of Christian Eriksen, Toby Alderweireld and Jan Vertonghen all entering the final year of their contracts.

"Mauricio and his coaching staff will always be part of our history," added Levy.

"I have the utmost admiration for the manner in which he dealt with the difficult times away from a home ground whilst we built the new stadium and for the warmth and positivity he brought to us. I should like to thank him and his coaching staff for all they have contributed. They will always be welcome here.

"We have a talented squad. We need to re-energise and look to deliver a positive season for our supporters."