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Facebook logo on Nasdaq's Times Square headquarters site. Reuters

The top after-market NASDAQ gainers Wednesday were Arris Group Inc, Take-Two Interactive Software Inc, ArQule Inc, General Communication Inc and ViroPharma Inc.

The top after-market NASDAQ losers Wednesday were Amicus Therapeutics Inc, Allscripts Healthcare Solutions Inc, Bed Bath & Beyond and NIC Inc.

Gainers

Arris Group Inc (ARRS) shares climbed 16.92 percent to $17.00 in post-market trading. The stock gained after it had been reported that the Google had agreed to Sell Motorola Home, a division of Motorola Mobility, to Arris for $2.35 Billion.

Take-Two Interactive Software Inc (TTWO) shares gained 5.81 percent to $12.68 in post-market trading. The shares lost over 5 percent in regular trading. The stock has a 52-week trading range of $7.37-$16.99 and a market capitalization of 1.09 billion.

ArQule Inc (ARQL) shares rose 4.90 percent to $3.00 in post-market trading. The stock has a 52-week low of $1.98, a 52-week high of $8.32 and $178.30 million in market capitalization.

General Communication Inc (GNCMA) shares advanced 4.74 percent to $9.67 in post-market trading. The stock has a 52-week trading range of $6.18 - $11.40 and a market capitalization of $384.91 million.

ViroPharma Inc (VPHM) shares went up by 3.42 percent to $23.92 in post-market trading. The shares have a 52-week trading range of $19.02-$33.17 and a market capitalization of $1.52 billion.

Losers

Amicus Therapeutics Inc (FOLD) shares declined 50.09 percent to $2.88 in post-market trading. The shares slumped following the failure of its investigational drug -- Migalastat HCL -- in a phase III fabry monotherapy study.

Allscripts Healthcare Solutions Inc (MDRX) shares slumped 18.73 percent to $8.68 in post-market trading. The shares dropped after the company had announced that its board member Paul Black was taking over as chief executive immediately, replacing long-time CEO Glen Tullman.

Bed Bath & Beyond (BBBY) shares dropped 3.87 percent to $57.95 in post-market trading. The stock has a 52-week low of $55.58, a 52-week high of $75.84 and $13.82 billion in market capitalization.

NIC Inc (EGOV) shares fell 3.56 percent to $15.72 in post-market trading. The shares gained over 4 percent in regular trading.