The top pre-market NASDAQ stock market gainers are: Santarus, MannKind, Logitech International, DryShips, Tesla Motors, JA Solar Holdings, Cisco Systems, Huntington Bancshares, optionsXpress Holdings, and American Capital Agency.

Santarus Inc. (SNTS) advanced 11.99 percent to $3.55 in the pre-market trading. The company and Pharming Group NV announced the submission of a biologics license application to the FDA to obtain marketing approval for Rhucin (recombinant human C1 inhibitor) for the treatment of acute angioedema attacks in patients with Hereditary Angioedema. The safety and efficacy of Rhucin were evaluated in two randomized placebo-controlled studies and are supported by four open label treatment studies.

MannKind Corp. (MNKD) jumped 6.02 percent to $8.45 in the pre-market session. The company said FDA informed on Dec. 27 that the agency will not be able to complete the review of the NDA for Afrezza Inhalation Powder by the action date of Dec. 29. The FDA said it will require about 4 additional weeks to complete its review of the NDA.

Afrezza is a novel, ultra rapid acting mealtime insulin therapy being developed by MannKind for the treatment of adult patients with type 1 and type 2 diabetes for the control of hyperglycemia.

Logitech International SA (LOGI) climbed 2.53 percent to $19.05 in the pre-market trading.

DryShips, Inc. (DRYS) soared 1.08 percent to $5.61 in the pre-market session.

Tesla Motors, Inc. (TSLA) surged 1.06 percent to $25.82 in the pre-market trading.

JA Solar Holdings Co., Ltd. (JASO) improved 1.01 percent to $7 in the pre-market session.

Cisco Systems, Inc. (CSCO) gained 0.89 percent to $20.34 in the pre-market session.

Huntington Bancshares Inc. (HBAN) increased 0.57 percent to $7 in the pre-market trading.

optionsXpress Holdings, Inc. (OXPS) rose 0.57 percent to $16 in the pre-market trading.

American Capital Agency Corp. (AGNC) moved up 0.44 percent to $30 in the pre-market session.

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