The Green Bay Packers host the San Francisco 49ers in the divisional round of the 2022 NFL playoffs, featuring the biggest point spread of the weekend. San Francisco upset the Dallas Cowboys on Wild-Card Weekend, while Green Bay earned a bye with the best record in the league.

Here are predictions for the spread, over/under and a couple of prop bets for Saturday's playoff game in Green Bay. Betting odds come from FanDuel Sportsbook.

Packers -5.5

Green Bay is the NFL’s best team, while San Francisco didn’t clinch a playoff berth until Week 18. The Packers have a massive advantage at quarterback with MVP favorite Aaron Rodgers playing opposite Jimmy Garoppolo. The Packers were perfect at home in the regular season, going 8-0 straight up and 7-1 against the spread.

The Packers beat the 49ers 30-28 in a Week 3 matchup that should’ve been more one-sided. Green Bay had a 17-0 lead right before halftime and was up 24-14 near the midway point of the fourth quarter.

Defensive stars Nick Bosa and Fred Warner suffered injuries for the 49ers in the wild-card round. The Packers are getting healthier after their first-round bye and should take care of business at Lambeau Field.

Under 47

The extra week off has allowed the Packers to bolster their defense. Cornerback Jaire Alexander will return from an injury, and edge rusher Za’Darius Smith could play for the first time since Week 1. Rodgers and Green Bay’s offense grab most of the headlines, but the Packers ranked ninth in total defense for the regular season.

San Francisco wants to control the clock and keep Rodgers off the field. Look for the 49ers to run the ball a lot, and they could do it pretty effectively, considering the Packers are second-to-last in yards per carry allowed. That means long drives and a potentially low-scoring game.

The 49ers are fourth in opponents’ yards per play, allowing 16.2 points per game over the last five weeks. The Packers give up 16.8 points per game at home.

Jimmy Garoppolo Under 243.5 passing yards

Remember, the 49ers want to run the ball. After throwing for 172 yards against Dallas, Garoppolo has never thrown for 220 yards in any of his four playoff starts, averaging just 150 yards per game. One of those starts came in the 2020 NFC Championship Game against the Packers, which saw the 49ers quarterback attempt just eight passes for a total of 77 yards.

Garoppolo is dealing with injuries to his shoulder and thumb. He’s thrown five interceptions in his last three games, including one last week that nearly cost San Francisco the game. 49ers coach Kyle Shanahan should stay committed to the run unless the score gets out of hand.

The Packers have given up 219.1 passing yards per game and held opponents to an 86.9 passer rating. In eight games at Lambeau Field, opposing quarterbacks have been sacked 21 times and thrown an equal amount of touchdowns and interceptions for a 74.9 passer rating.

Aaron Rodgers first touchdown scorer +2800

At nearly 30/1 odds, there’s value on Rodgers to score the game’s first touchdown. The quarterback ran for three touchdowns in the regular season. Rodgers ran for a score in Green Bay’s first home playoff game a year ago.

San Francisco gave up a rushing touchdown to Dak Prescott in the wild-card round. Marquez Valdes-Scantling is doubtful for Saturday, likely eliminating Rodgers’ third-best receiver as an option in the red zone.

Rodgers won't be afraid to run for a score and put his body on the line with a trip to the Super Bowl just two wins away.

Aaron Rodgers Green Bay Packers
Aaron Rodgers #12 of the Green Bay Packers leaves the field following the NFC Divisional Playoff game against the Los Angeles Rams at Lambeau Field on January 16, 2021 in Green Bay, Wisconsin. Stacy Revere/Getty Images
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